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06-18-2008, 09:20 PM | #11 | |||
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Thanks to ALL for saying hello and welcome. I know I will make the 10 post qualification however it did take me 2,756 posts on Braintalk before I was banned as jackD. I hope to make it to at least 3,000 here. I was reborn again as Braindead on Braintalk. I now have 338 posts as Braindead. jackD AKA Braindead Jack N Dalton |
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06-18-2008, 10:45 PM | #12 | ||
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Yappiest Elder Member
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amn is over 5000, you should be safe. she does bribe the mods.
heck..i'm over 9000 and doc still puts up with me.
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"Thanks for this!" says: | SallyC (06-19-2008), Twinkletoes (06-18-2008) |
06-19-2008, 10:09 AM | #13 | |||
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In Remembrance
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Welcome to Neurotalk, Jack and, so far, I really do mean that. Don't expect us to be rude, as, they have always been, at that other place.
I remember your good posts, but, unfortunately, I remember some of your umm...not so good, posts, as well. Please treat us with the same respect you would expect for yourself, and all will be great. I have always been interested in the MMP-9 theory, and finding something to counteract the damage it does. Have you found anything safe, we can add to our supplement regimine, that has helped to accomplish this noble feat? Again, Welcome Friend and let us know if there is anything we can do to support you, in your fight against MS. We are even allowed to have some good clean fun, here......visit the Stumble Inn (cute huh?) and find out.
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~Love, Sally . "The best way out is always through". Robert Frost ~If The World Didn't Suck, We Would All Fall Off~ |
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"Thanks for this!" says: | Curious (06-19-2008) |
06-19-2008, 11:57 AM | #14 | |||
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Sally I am glad to be here and hope to contribute a lot of practical helpful info. I have some VERY GOOD info on how to reduce/lower those nasty MMP-9s populations but must wait until I have 10 posts before posting it because I am trying to fool them into thinking I am a nice guy and I must show some pics and .pdf stuff on my web storage area and some links. But you just wait until I get my 10 postings and the REAL JACK will appear!!! jackD |
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06-19-2008, 12:04 PM | #15 | ||
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Yappiest Elder Member
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jack, be sure you read the guidlines about posting articles. especially about copyright. we can't post full articles. just a few sentences and the link MUST be included.
we had some backlash from from some authors. i fyou have any questions, please pm me. oh...and pm the links to the ones you posted. i don't want to have to pull them. the edit time may have expired for you to include them.
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06-19-2008, 01:33 PM | #16 | ||
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Thanks for all of the information. It is going to take me a while to read through it!
I have Optic Neuritis and 5 children to take care of. Not much time to read! But I do appreciate the help.
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LA Optic neuritis May 2007 and again January2008 Diagnosed February 13 2008 Started Avonex February 22 2008 (still progressing) July 2009 started Betaseron..... "Don't argue with an idiot. People watching may not be able to tell the difference." |
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06-19-2008, 01:49 PM | #17 | |||
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Keep up the fight and you can overcome the other big MS problems like cognitive loss and excessive fatigue. jackD |
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06-19-2008, 01:52 PM | #18 | |||
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If you want to maximize Avonex (or any beta interferon), lowering MMP-9s will prevent it from being degraded by being cleaved into parts thus killing its Activity/Effectiveness.
http://www.cnsforum.com/commentedite...9/default.aspx Also getting the most activity from the least amount of near natural (human) interferon like Avonex will usually result in MUCH LESS neutralizing antibody formation (2-5% vrs 20-26%). Unfortunately for MS folks (MMP-9s) also like to cut a hole in our BBB Blood Brain Barrier and then enter the brain and cut our myelin into three components that the other hungry characters like to dine on. This mechanism of destruction caused by excessive agressive MMP-9s is a good target for reduction and should reduce MS damage if lowered a tad. Actual abstracts and one major study on my web page are provided below. http://home.ix.netcom.com/~jdalton/Yongrev.pdf SEE FIGURE 2 and MS info on page 505 Things that reduce MMP-9s (AKA gelatinase B) This list of GOOD "things" for MS should seem familiar - This is WHY??? VIT D3 .................................REDUCES MMP-9s RESVERATROL (Grape Skin Extract) ...REDUCES MMP-9s (NOT GRAPE SEED EXTRACT) GREEN TEA EXTRACT(EGCGs)... REDUCES MMP-9s ALPHA LIPOIC ACID (R-lipoic/ R-Dihdro-LipoicAcid) ... REDUCES MMP-9s NAC N-Acetyl-L-Cysteine .......REDUCES MMP-9s STATIN DRUGS (i.e Zocor) .....REDUCES MMP-9s Omega-3s (ie Fish oil) ...........REDUCES MMP-9s Minocycline/Doxycycline.........REDUCES MMP-9s Curcumin.............................REDUCES MMP-9s Pycnogenol (Pine bark extract)..REDUCES MMP-9s Chondroitin sulfate (CS) and CS plus glucosamine sulfate (GS) ..REDUCES MMP-9s Interferon Betas 1a/1b...........REDUCES MMP-9 (of course Steroids ....REDUCES MMP-9s) ***NOTE*** ( gelatinase B = MMP-9) ***NOTE*** I have lots more information on this MMP - MS - INTERFERON-beta connection and will elaborate it if there is some interest in this subject here. Jack n dalton - jackD Quote:
Last edited by Chemar; 06-20-2008 at 03:01 PM. Reason: quote tags added |
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06-19-2008, 02:05 PM | #19 | |||
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Since lots of MS folks think that taking "Grape Seed Extract" is good and I have posted the opposite I will provide my reason for having my opinion.
IF and ONLY if we accept that increasing GAMMA INTERFERON is BAD for MS folks will my argument prove sound. I would hope that everyone can accept this as a fact. Some Gamma Interferon at low levels is necessary for good health and myelin repair. The medical literature shows that ADDING/INCREASING Gamma Interferon has worsened MS folks in clinical studies. jackD Quote:
Last edited by Chemar; 06-20-2008 at 03:06 PM. Reason: adding correct quote tags |
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06-23-2008, 01:36 PM | #20 | |||
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This thread is a bit of a mess.. so I will get off the main track without fear of destroying the beauty of this messy thread.
This study from Lebanon shows that MMPs do the actual damage in BOTH rheumatoid arthritis (RA) and osteoarthritis (OA). I have found that my MMP reduction program of supplements has done wonders at reducing mr OA arthritis. I have had both kneees operated on and things were still so bad I walked around my house on crutches. My finger joints were red and swollen and VERY VERY SORE. MY thumb was almost useless because of the pain generated at the base of the thumb when I used my right hand. Since I started my MMP-9 reduction program I have had NO pain for the last 6 yes!!! Yes - no more crutches, no red finger joints, no more annual shots in the knees!! You must also reduce interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1 beta) and maybe IL-12 also. That is no BIG deal because some of the MMP-9 reduction "thingies" does this also quite well. jackD P.S. For more info go to PubMed and search on "MMP arthritis". P.P.S. - It is real shame that this Medical folks cannot find ways to reduce these nasty MMPs. I had no problem and have discovered two more "thingies" that reduce MMP-9s in the las two weeks. I will post them later after more research. http://www.ncbi.nlm.nih.gov/pubmed/1...?dopt=Abstract Quote:
Last edited by jackD; 06-23-2008 at 02:10 PM. |
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