Did anyone else experience the following while on LDN: I get pre-charley horse like feeling in my left calf and also numbness in both hands between 3 and 6 am every morning. I have also occasionally been experiencing cramping in my toe at that time on my left foot. I might add my left leg/foot drop is my biggest problem with mobility.

I started at 3.0 (5 weeks) went up to 4.5 (5 weeks) and dropped back down to 3.0 due to muscle spasms. I am presently on 3.0.

I am going to be getting a MRI in December. It will be after being on LDN for 6 months. I'll let you all know if there is a difference between my last one in10/2007.

I think the only reason the doc wants one this year is because of the LDN.

I am ecstatic for those who do so well on LDN.

Good luck on your MRI , Tree, next month when you get it. That would be great news if it's improved.

It does my heart good ( as my Grandmother used to say) to hear how LDN is helping you all....Either in a big way or a small way, at least you are feeling better.

Thank you, Sally, for starting this thread. I would never have known about LDN if it had not been for this thread and all the folks who've contributed to it!

AND...Thanks to Curious, for making it a sticky..

Cherie and flutemaker...well thought out responses, thank you. My husband and I came to a lot of the same conclusions over dinner last night.

It seems to me, from my research and many of the responses here, that the main benefit from the LDN is a reduction in the other meds taken for depression, etc. In my mind...that is a good thing for those that need that.

I don't take any other meds and really don't have a lot of pain - minor annoying sensations or numbness - that goes away quickly. My main issue is fatigue, which goes away in between relapses...I have only had three. So it is still a question in my mind...do I need LDN? Will it cause unnecessary side effects?

I guess as I look at the whole picture, if I'm going to take a medicine...LDN seems the most logical and the most aligned with my belief that I need to work "with" my body.

Can I admit to this group? I am still confused and wish someone had the "answer", but then I guess if someone did...we would ALL know.

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Can I admit to this group? I am still confused and wish someone had the "answer", but then I guess if someone did...we would ALL know. [/QUOTE]

Brenda,
A lot of it seems to be trial and error. You're not alone in feeling this way. I've been diagnosed since 1999, had my first exacerbation that was misdiagnosed in 1992. Started Copaxone in 1999. Do I know that I'd be worse off if I wouldn't be on Copaxone these 9 years? No. But it does our hearts and our heads good when we know we're doing something that might slow this beast down. Whatever you ultimately decide, I wish you well and you know we're here for you.

I found this in the interview with Dr. Bihari today at gazorpa.com through the lowdosenaltrexone.org website...I am REALLY EXCITED about this! You all probably know this already:

Dr. Bihari: Not directly. It's more that the autoimmune diseases are beginning to
look more and more like they’re diseases of endorphin deficiency. [Inaudible] models
of all the diseases I mention that can be bred in mice, the endorphin levels are always
fifteen to twenty percent of normal compared with normal mice.

[Female Voice] How can you naturally increase endorphin levels?

Dr. Bihari: There's only three or four ways that I know. First, Naltrexone increases
them substantially, two to three hundred percent in people with low levels. Second,
aerobic exercise increases them, but not as much. If you do an hour of exercise four
or five times a week it will last three, four hours, and that's one of the reasons that
exercise helps prevent cancer. A third way, oddly, is acupuncture. Acupuncture,
especially when used in treating addicts, increases endorphin levels in the blood and the
spinal fluid. And chocolate increases it.

So...as I understand it, the recommended treatment is:

1. LDN
2. Exercise
3. Acupuncture
4. Chocolate

Shouldn't chocolate come before exercise??

On second thought....who cares!! As long as it's in there somewhere!!

**running off to locate the leftover Halloween candy!!**

I'm lovin' this LDN therapy more and more everyday!!

I wonder how Dr Bahari is? Has anyone heard? He was ill for a while...He is up there in age.

Well Mom, except for the acupunture and exercise you just mentioned my total diet..