I sent a quick e-mail to my brother last night and when he got into his office in the morning, he send a quick reply.

I just wanted to run it by him to see if he had heard any negatives.

As you read, he is not familiar with the drug at all.

All the websites referenced seem to center around one doctor or Skip's pharmacy. Even the .org (which is for me, more reliable) said that LDN had not been tested for MS.

I also asked my friend, a pharmacist, who mixes this compound for patients. She has no MS patients but does make it for others. She had no problem with the low toxic dosage.

I hope I helped with your confusion...

Thanks, Aarcyn.

What you've said is exactly the reason I made my prior comments to Erin:

Neurologists and MS Specialists do not normally have any experience with this drug . . . so I appreciate that this may be treading on unfamiliar territory for them. I have noticed that GP's are much more likely to rx LDN, probably because many have previously prescribed it for other purposes, at a MUCH higher dosage.

Naltrexone is just a minute dosage of a very well-established medication. That they haven't done many large trials on the toxicity of LOW DOSE Naltrexone is probably a moot point. That would be like saying that Ibuprophen has been safely trialed at 5X it's recommended dosage . . . BUT it has not been trialed at 1% of that dosage (so we don't know it's toxicity at that level ).

I agree there isn't any scientific proof of LDN's efficacy for MS. There are a lot of (especially symptom) meds we take that have never been trialled for MS specifically. Only anecdotal evidence exists that they may work for us, but that doesn't stop our doctors from prescribing them when we ask though. . . .

Cherie