I've had to lower/increase the dosage of LDN when the weather changes, every year. The spasticity comes back (for me) in cold weather, but it usually takes me a few weeks (DUH!) every year to figure out what's going on . . . but when I do, I drop down to about 3.5 - 3.75mg, and I am good. I always work my way back up to 4.5mg within a few weeks though.

As far what happened last year with the infection, I had a broken root under a cap in my tooth. It took a while for my dentist to figure out what was causing the pain, but when he did he said that he could just keep putting this numbing med in so I could hold onto the tooth (molar) as long as I wanted.

What didn't occur to me is that every time it got "inflammed", it was actually infected.

Since I had that ongoing infection, my immune system got very weak. I think I got three bacterial infections, bronchitis, a couple of colds/flu's, some UTI's (with no notable symptoms, except MS ones), and I can't remember what else. ANY type of infection can cause us problems though.

My spinal lesions flared up every time I wasn't on antibiotics, and I was on/off them several times. When the lightbulb finally went on (about the tooth being the underlying cause), I had it removed. My spinal lesions quit acting up almost immediately, but by then I was left with some long-term (or permanent) damage, including heat sensitivity and numbness.

I am still at the same EDSS that I dropped to after 9 months of being on LDN, but I have more issues due to the 2007 infection year.

Cherie