Nope, no weight loss for me. But I am currently on an AD, so am optimistic I'll have a similar experience to Cherie's. I really need to lose weight! *insert chubby icon here*

I just increased my dose to 4.5 mg.

And Frank, I know what you mean about waking up feeling sluggish.

Yesterday I was ready to throw in the towel, even though I promised myself I'd give it a good effort. I've only been on LDN for 7 weeks, and that really isn't long enough to give it a chance.

To start with, my symptoms weren't as severe as many of you (just diagnosed 1.5 years ago), so maybe that's why I've noticed more unpleasant side effects of the LDN (b/c I had less to celebrate).

The one positive thing that I've really noticed (most days) is improved stamina. Even if I don't wake up feeling very energetic, as long as I get moving I can go all day.

For instance, today I got up and took a mega-dose of Ibuprofen b/c I was achy. I was able to get ready and get on a plane at PHX airport, land in SLC and drive 2+ hours home. I still had energy when I arrived and actually unpacked my bags (something I almost always procrastinate due to lethargy). It's past 10:30 p.m. now and I am tired, but not dragging.

The clincher will be if I am able to make it to church in the morning by 9:00. If I can just get beyond the body aches, I'll be okay. The body aches and sluggishness are what prompted me to give up on Copaxone after 9.5 months.

I really do not want to try any of the other CRABs or Tysabri. I'm hanging all my hopes on LDN.

Glad you all are experiencing positive effects. But I wanted to be honest about my experience because, for those looking into using LDN, its good to weigh the pros and cons before making a decision.