Yes, many men and small/tiny women (around 100 lbs) can not tolerate more then 3.0 mg, and others with spasticity problems sometimes can't either. For some of us the spasticity is just a transitory initial side-effect, or occurs only during cold "weather", etc, so it may require some trial and error/flexibility to find out what works best for us as individuals.

I couldn't get up to 4.5 mg for about 6 months, and have to drop down for a few weeks every Fall when the colder weather hits . . . however for the rest of the year I am fine at 4.5mg.

3.0 mg is the "ideal" dosage and sufficient for many of us (according to Dr B), so I wouldn't be too concerned with forcing the 4.5 mg dosage level. We are still "protected" at 3.0mg . . . it's just that some of us are determined (for no particular reason ) to keep trying to get to 4.5 mg. That dosage may CAUSE problems for some, or IMPROVE symptoms for others . . . so it's a matter of finding what works best.

You are welcome, Mom2Five.

Cherie