http://www.fiercebiotech.com/press-r...rucotide-mbp82


Has anyone heard of this drug? My son's girlfriend sent me an email about it.

No I haven't Kelly, but I'm always open to learning about new treatments.

Thank you for the link.

Kelly, no I have not heard of this study or drug. Sounds very interesting, and from what i think I read, its nearing its final phase in testing. Thanks for sharing this, like Anne said I am also always up for reading about a new treatment

It is MBP8298, this is probably the article referenced: http://www.medicalnewstoday.com/articles/118192.php The Maestro-02, Phase II/III study in Europe and Canada seems to have been successful.

I've heard of it. It's a synthetic make of 17 pepitdes mimicking mylein make-up. I follow the phase III trials with interest

Correction- 17 Amino acids to make up a peptide.

There's quite a bit of information about it on this site:

http://www.msrc.co.uk/index.cfm?fuse...ow&pageid=1308

"Kenneth Warren, M.D., director of the MS Clinic in Edmonton, and Ingrid Catz, M.Sc., researcher at the University of Alberta, have developed a synthetic segment of myelin basic protein called MBP8298. The researchers have been involved in the development of MBP8298 for more than 20 years. The investigators have given the product to approximately 100 people over the past 10 years in both Phase I and Phase II clinical studies. They report that of 41 people with progressive MS, 61% went into remission as measured by antibody levels in spinal fluid. The investigators report there are no clinically relevant side effects in those who have been given MBP8298 to date."

http://www.mssociety.ca/en/research/...date-dec04.htm

From info I've read/discussions I've seen:

The mode of action is apparently similar to Copaxone, but it is given via IV once every six months, and is considered very safe compared to many drugs we take.

It is thought to work by inducing immune tolerance, much like an allergy shot, i.e. "flood the body with the antigen (in this case a self-antigen, i.e. myelin) and the immune system learns to ignore it."

The drug seems to effective in those of us with HLA-DR2 or HLA-DR4 genes, but apparently about 75% of us carry this genetic type.

Cherie

IV once every 6 months? Very nice. Let's hope it continues to show such promise

A twice a year medication with no relevant side effects?

*standing in line early*

Apparently one of the main two intial researchers has a wife with MS. He had a vested interest.

The best part is if it works this well on PPMS and SPMS . . . what is the potential for RRMS?

Cherie