Sheena, a very large % of our lesions don't even show up on a MRI, so there is no way for sure to know if there is inflammation going on "somewhere".

Additionally, a lot of times the activity that causes this is from our spine, and they don't always MRI that every time. Those lesions don't enhance the same way either . . .

There is the chance too that there was axonal damage from that last big flare, that doesn't heal. Even when we don't have "activity" going on in our MRI's, axonal damage continues to occur (this is very obvious by those with SPMS and PPMS, many of whom don't often have visual "activity/inflammation" in a MRI, but continue to progress with the disease).

An MRI is really just a dx tool IMHO. After that, the best measure of how we are doing is "how we are doing".

Cherie