I experienced 5 IPIR's that sound similar to yours in the 4 1/2 months I was on it, and then both I and my neuro threw in the towel. I also experienced the cold chills and shaking after all the other heart/shortness of breath/flushing ... symptoms were over and they lasted for about 2 hours each time. I can't believe you hung in after having 20 of these. Wow! My neuro has suggested imuran as a possibility, but right now I am just having a MRI every six months to check progression. I feel so much better now than one year ago when I was on copaxone.

aww you poor kitten. 20 is just too many!

I hope you are feeling better soon.

I completely understand! I quit it after 11 mos, 2 weeks because of the frequency and increasing severity of the IPIRs. I HATE that drug!

I take 15mg of Methotrexate every week now. Pills...no more shots. They did nothing and I progressed steadily through all the treatments. No slowdowns for me.....

You WILL feel better without that crummy drug!

I feel like such a weenie! I threw in the towel a month ago because of IPIRs that I had been having. Mine are different and didn't affect my breathing or heart but were very painful in my back, neck and head. After the last one where I couldn't walk for about 5 minutes because of the excruciating pain I said NO MORE!

My neuro surprised me and talked me into trying Avonex before trying Tysabri. So nurse should be here next week to show me how to do the IM shot. Wonderful, not!

I hope you find something else that works for you.

Having never experienced an IPIR, I do think that those who experience them frequently are making the right decision by either choosing another drug option or going natural/drug free.

Best to all of you