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Old 09-30-2008, 12:37 PM #1
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Originally Posted by Erin524 View Post
I'm not on an interferon. But I have insomnia that's really horrible. I'm trying to not blame this on the MS, because I dont like having everything blamed on the MS, sometimes there are other reasons.
You may not want to blame the MS for the insomnia but my main point was that MS IS probably the main culprit. Pro-inflammatory cytokines like Gamma Interferon and TNFa which are elavated in MS cause lots of damage to lots of things.

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It turns out that pro-inflammatory cytokines cause tryptophan to degrade in the blood. This occurs because these pro-inflammatory cytokines activate specific enzymes that deplete tryptophan in the bloodstream.
I only mentioned the Interferon Beta contribution because the referenced link included that comment and IFN-Beta users may suffer more from insomnia and depression.

The relation to MS depression should also be noted. Insomnia, depression and fatigue are an awsome burden for us MS folks. It appears that treating the insomnia will also help treat the depression problem.

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The result of diminished blood levels of tryptophan is serotonin deficiency in the brain (and the onset of depression).

I have purchased some L-Tryptophan and intend research the proper dosage and give it a try.

jackD

Last edited by jackD; 10-01-2008 at 12:04 PM.
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Old 09-30-2008, 04:25 PM #2
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I have purchased some L-Tryptophan and intend research the proper dosage and give it a try.

jackD
I took 1 500mg capsule a night, but since mine is though a compounding place, not sure what's all in it.

It IS covered by my medical insurance through work, surprisingly

It did help me to sleep for sure!
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Old 09-30-2008, 04:43 PM #3
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I took 1 500mg capsule a night, but since mine is though a compounding place, not sure what's all in it.

It IS covered by my medical insurance through work, surprisingly

It did help me to sleep for sure!
My L-Tryptophan comes in 2,000 mg capsules and the bottle says that "Serving Size: 4 Capsules".

This is why I am going to do a bit more research on the amount to take to get a favorable sleep results.

jackD

Last edited by jackD; 10-01-2008 at 09:54 AM.
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Old 10-01-2008, 09:16 PM #4
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Originally Posted by Erin524 View Post
I'm not on an interferon. But I have insomnia that's really horrible. I'm trying to not blame this on the MS, because I dont like having everything blamed on the MS, sometimes there are other reasons.
I really do agree with you. As I age I could blame many things on MS. I don't think all the symptoms, health problems are from MS, but there is a tendency (not unfounded) to blame MS.

So many symptoms of MS are similar to other things; I suppose that's why neuros do so many tests.

I have friend and family who have insomnia. Some people say to drink a glass of milk at night and it will help. I don't know but it's an easy thing to try!

One of my family members had been suffering from insomnia for as long as I can remember. She doesn't have MS or thyroid problems. Who knows why she has it.

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Old 10-02-2008, 03:22 AM #5
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I suffer tremendously with insomnia. If I get to bed before 3am, it is a GOOD night. And this is even with taking ambien every night. Sometimes I take something in addition to that, in hopes of knocking myself out. Doesn't always work.

I have noted that my insomnia peaks and gets MUCH worse right at the onset of an exacerbation. In fact, my first exacerbation - which led to diagnosis - came right after having a 2-3 week period of not getting to sleep before 6am and even then struggling. Of course, immediately after that period, I couldn't move and the fatigue was out of control.

I'm thinking of going to a sleep study place (doc referred me and insurance will pay), but I'm chicken...the thought of being hooked up to wires and wide awake, unable to sleep with no TV, 'puter, or books to keep me occupied.

I've tried every sleeping pill, none work any better than the ambien (which I've been on since January).

Right now, the insomnia seems worse and I'm afraid that it means something bad is around the corner.

~Keri
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Old 10-02-2008, 11:16 AM #6
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Originally Posted by RedPenguins View Post
I suffer tremendously with insomnia. If I get to bed before 3am, it is a GOOD night. And this is even with taking ambien every night. Sometimes I take something in addition to that, in hopes of knocking myself out. Doesn't always work.

I have noted that my insomnia peaks and gets MUCH worse right at the onset of an exacerbation. In fact, my first exacerbation - which led to diagnosis - came right after having a 2-3 week period of not getting to sleep before 6am and even then struggling. Of course, immediately after that period, I couldn't move and the fatigue was out of control.

I'm thinking of going to a sleep study place (doc referred me and insurance will pay), but I'm chicken...the thought of being hooked up to wires and wide awake, unable to sleep with no TV, 'puter, or books to keep me occupied.

I've tried every sleeping pill, none work any better than the ambien (which I've been on since January).

Right now, the insomnia seems worse and I'm afraid that it means something bad is around the corner.

~Keri

You sound worse than I did/do. Hopefully you get something figured out so that you can sleep. It's torture when your brain wont let you sleep.
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