So happy for you, Lady! Great news!

Kitty, I've changed the time I take my LDN and now can fall asleep much faster at bedtime. Right now I'm taking it at noon, but am gradually working my way towards taking it with morning meds (including thyroid pill).

It never would have occurred to me that LDN was affecting my sleep if you hadn't mentioned it. Thanks!

Hey, Twink! I'm sleeping better, too. I take my LDN anytime between 4 AM - 7 AM. I try to take it as close to 4 AM as I can.....but I take my thyroid med when I first get up and I think you have to wait about 30 minutes after taking it (thyroid med) before you take any other med. Something about the absorption of the thyroid med. Good luck!

The reason that Dr Bahari said to take LDN with a fast release filler, at bedtime and before 3am, is because, our endorphines are usually replenished in the wee hrs of 3am to 5am and by blocking this temporarily, our endorphins then are fooled into doubling, because of the temporary blocking.

If your clock is off kilter a bit, then taking LDN at an earlier time may be ok for you. I wouldn't advise all to change, though, because the reason is still there, just maybe not for everyone.

If you find that the LDN may not be doing the job it was, then, switch back to the 9pm to 1am time.

Hi Kitty taking LDN 4 am to 7 am is probably when YOU make your endorphins because you go back to sleep after that. I can see that working for you.

I think the whole benefit of this drug may be trying a little time changing, like we change the clocks, does our bodies know that now endorphins should be made at a different time? No.

Some set a clock and take their LDN in the middle of night if they go to bed early, like 9 pm. That may be too early to take the fast release type drug that this is. If you take the liquid it really kicks in right away and may not help when you need it during sleep, if you go to bed early.

This may be the answer as to why the drug helps some and not others who try it.

I don't think daytime is a good time to take LDN, as how would it benefit? I believe taking it at a night time sleep is the best time, but maybe adjusting it a few hours before or after your usual time, will work better because we are all so different.

Do I make extra endorphins at 3 am, or 6 am? Maybe 2 am or 4 am. 5 am or it might be 2:30 am to 4 am. If I am a late night person do I make them later in the night or early in morning?

I believe there is a variance so to play with LDN times may be a good thing. If it is working for you and you sleep well then don't change a thing. If not, then varying it a little might work better for you.

I know once I take it, I can feel the drug doing something, so I make sure I get right to bed. Staying up later will make me feel weird. I know it's trying to work but I am not a sleep yet.

I hope I got this out right, so my thoughts are understandable. JMO
Anyone think this has merit? I am not a pro on this LDN, just trying to reason it out. There might be more responders to the drug if it is varied a bit.

It's true, Lady, nothing is set in stone and our bodies are all different and react to meds in different ways at different times.

Does anyone notice a sudden burst of strength and energy at about 4am? I usually go to bed at about midnight and take my LDN at 11/12midnight.

I have a habit of waking at around 4am to go potty and I notice this burst and think, that this must be the Endorphines doing their thing. I go back to sleep, but not right away. I rather enjoy the moment.

My time capsule seems to be working, so I won't change, now, but I have changed times over the years.

I am just starting LDN and have heard different views on the mgs to start with.

What dosage did you all begin with? and What is your current dosage?

Did anyone notice that they did better on 3mg than 4.5mg or the other way around. I read somewhere, that women tend to take the 4.5mg.....any truth to that?

thanks so much.

I started out on the 3 mg dose and stayed on that for a long time. First time I tried to bump it up to 4.5 I got spasticity in my legs. Went back to 3 mg. I think I tried to increase it a couple of times before I finally was able to tolerate it. The last time I tried it just "worked" for some reason. I've been on 4.5 ever since.

I also could tollerate only 3mg, in the beginning, and after about 2 years went to 4.5mg, without a problem. I didn't notice a difference, really. It's all good!!

I know peeps who stayed on 3mg for the past 7 years and some who started out and stayed on 4.5mg for the past 12 years.

Dr Bihari(Our Founder) calls 4.5 the ultimate doseage for LDN and yet admits that some do better on a lower doseage. We are all different.

sally....

if you didn't notice a difference between the 3mg and 4.5 mg why not just stay on the lowest dosage that works?

I think the less medication the better.

This is all so new to me. and now I have had an EEG with spikes in the left parietal lobe. (on one 20 minute EEG) I am scheduled for a 3 day EEG now.

sooooooo overwhelmed. Do you know if LDN is used with seizures?

Since Dr Bihari said that 4.5mg was the optimal doseage, I thought I'd try it to see if I liked it and I did..