I have itching too - I'm on Zonegran. It's actually an epilepsy drug. From what I understand, Zonegran fools the brain into not receiving the phantom itching messages from MS itching. Topical creams don't work with me because it has nothing to do with your skin (unless you scratched the area so hard that you've created sores), it's the nerve endings only. Mine is constant and I have tio take this Zonegran probably for the rest of my life. If I forget to take ther pills for a day or two... I am unpleasantly reminded!! But it does work!!