Thanks for this. I just giggled when I saw the autopsy revealed "active" lesions...pffft....too funny when they word things like that.

Really!! If they're "active" during an autopsy what on earth are they considered beforehand!?

I have NO HUMOR for you but I do have some more info..

PANIC!!! PANIC!! PANIC!!

MS is a TWO STAGE DISEASE!!!

1st is THE INFLAMMATORY Stage - Standard DMD work well here.

2nd is the NEURODEGENERATIVE PHASE The Standard DMD is weak and mostly unknown. However LDN may be effective for this stage of MS. In classic MS you have about 10 years of R/R MS followed by the next, 2nd phase which severly reduces mobility and loss of leg strength. Treatment with DMD during R/R stage could delay or hopefully avoid this stage.

http://home.ix.netcom.com/~jdalton/ms-two-stages.pdf

http://home.ix.netcom.com/~jdalton/two%20stage%20MS.jpg


jackD

P.S. Look a the pic and guess what needs to be reduced or blocked. Hint it begins with the letter "g".

Do you take LDN?

gmi

NO. I never considered taking LDN because I was on Avonex for over 10 years.

The info that LDN was found to counter Glutamate nerve toxicity is very new and I will post it here as soon a I can find it again.

FounD It!!!!
.
.
http://autoimmunedisease.suite101.co...rosis_variants
.
jackD

I read the article. It appears to be about the only thing for SPMS and I would try it if I could find a doctor to prescribe it. One major problem is that MSG is in almost everything!!

gmi

I have been researching how to reduce Glutamate levels and thus Glutamate nerve toxicity for some time. I have not had any new or enhancing lesions in over 8 years but I am having increasing problems with my legs and mobility.

I think that now that the Myelin has been removed from my nerves that they are now "lunch" for some nasty critters and the Glutamate factor seems to be the number #1 suspect.

The body does produce a substance to counter this kind of damage but it cannot be taken as a supplement or medication.

I do have short list of "things" that may cause the body to produce more of this substance. My recent computer crash and a few trips to the emergency room for things not directly related to MS has slowed down my research and prevented me from posting on this subject.

I will try to post individually what I have found and what I am taking in the hope? that it will help. Obviously avoiding things that elevate Glutamate levels (like MSG) comes first.

jackD

I subscrube to the stages of MS but I think it can be considered neuro-degenerative even in the inflammatory stage. When axonal damage is confirmed in the brain of a most definitely RRMS patient, wouldn't that in fact be considered neuro-degenerative?

I had actually read a lot this when I was first dxed, that researchers were beginning to look at MS as a neuro-degenerative disease altogether.