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Myasthenia Gravis For support and discussions on Myasthenia Gravis, Congenital Myasthenic Syndromes and LEMS. |
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#11 | ||
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Senior Member
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from the PDF attached to Annie's post, above
"...asymmetric ptosis is most often associated with acquired and autoimmune myasthenia gravis (MG) in contrast to CMS and other inherited disorders. He and his coworkers studied the diagnostic value of this observation by comparing a group of patients with autoimmune MG or Lambert–Eaton myasthenic syndrome (LEMS) with a group of patients with hereditary myopathy. Studying the files of 250 MG or LEMS D. Beeson et al. / Neuromuscular Disorders 15 (2005) 498–512 505 patients and 83 hereditary myopathy or CMS patients (dystrophic myotonia, progressive external ophthalmoplegia, oculopharyngeal muscle dystrophy, CMS) revealed a similar frequency of ptosis in both groups (76 and 78%, respectively). Asymmetry was noted in 80% of the MG or LEMS patients and in 30% of the myopathy or CMS patients. To verify these findings, a prospective study was started in which the ptosis was quantified using digital photography. So far, 52% of 23 MG patients and none of 20 myopathy/CMS patients were found to have a significant asymmetric ptosis. The results of these ongoing studies suggest that asymmetric ptosis points to an underlying autoimmune disease and less likely towards a hereditary myopathy or CMS." |
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