Myasthenia Gravis For support and discussions on Myasthenia Gravis, Congenital Myasthenic Syndromes and LEMS.

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Old 08-25-2012, 09:59 PM #1
hajile99 hajile99 is offline
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I guess I'm not trying to infer that the drug caused the disease, per se, but perhaps it had remained stagnant in my body (or perhaps manifesting in smaller, less noticeable ways that I may have ignored or just thought was "normal") and was brought out more substantially due to this medication. Again, this is all theoretical, to a degree, because I'm not entirely sure what's going on with my body.
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Old 08-26-2012, 07:34 AM #2
Anacrusis Anacrusis is offline
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Quote:
Originally Posted by hajile99 View Post
I guess I'm not trying to infer that the drug caused the disease, per se, but perhaps it had remained stagnant in my body (or perhaps manifesting in smaller, less noticeable ways that I may have ignored or just thought was "normal") and was brought out more substantially due to this medication. Again, this is all theoretical, to a degree, because I'm not entirely sure what's going on with my body.
Hi Adam

I am really interested in this topic. You got some good answers here.
Please mail me any new info you stumble upon in the near future!

In January I thought I had nailed it right on the head – stopped taking drugs that were on an MG list and symptoms cleared completely two weeks later. Re-challenge tests with the drug in question brought back symptoms 12-16 hours after administering it EVERY single time. I had read that any drug induced myasthenic symptoms clear up completely upon withdrawal of the offending substance. And very nicely all my symptoms fell silent for quite a few months without this drug. And so I thought, great stuff! I´m done with all of this now. But now 8 months after being completely medication free, symptoms are sneaking up on me (though in milder forms) and I realize in my case as well the drug probably had more to do with the ´unmasking´ process that 4-eyes was referring to rather than actually being responsible for causing MG. And that is how I arrived at what you yourself describe as something´stagnant´in the body. (I also call it something ´latent´ )

What is also interesting to me is how a drug I used before pregnancy never even gave me a single measly side effect yet now it can cause so much havoc and destruction.

It´s really hard to know that some of our questions about what´s going on in our bodies we may find answers to - whereas others we may never find answers to.

But I´m wishing you continued good luck in your research towards good health anyways!


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Old 08-26-2012, 01:02 PM #3
kathleenob kathleenob is offline
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Default The med list...

I found the article that was referred to above. ACTH and corticosteroids prednisone
Analgesics narcotics
Anesthetics, local cocaine, procaine, lidocaine, bupivacaine, prilocaine
Antacids or laxatives containing magnesium Maalox, Mylanta
Antiarrhythmics quinidine, lidocaine, procainamide
Antibiotics aminoglycosides, quinolones, telithromycin, azithromycin, erythromycin, clindamycin, ampicillin, imipenem, vancomycin, metronidazole
Anticonvulsants phenytoin
Antihypertensives beta-blockers, calcium channel blockers
Antimanics lithium salts
Antipsychotics chlorpromazine
Antirheumatic chloroquine
Arthritis agents penicillamine-induced myasthenia gravis
All neuromuscular blocking agents
Antimalarials chloroquine, hydroxychloroquine
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Old 08-29-2012, 05:41 PM #4
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Z-pacs (that seemingly great one a day for 6 day antibiotic) are on the list but not as Z-pac's by name arithzy...something like that, but it is a ZPAC
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Old 08-30-2012, 10:46 AM #5
Anacrusis Anacrusis is offline
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Just wanted to throw something contradictory into the pot here, about contraindicated drugs and my own experiences:

The exact same drug that was provoking myasthenic weakness 8 months ago is the exact same drug that I was taking last spring when I went into quite a significant remission whilst in the process of actually taking it. (My progressive myasthenia felt like being on a 5 year roller coaster ride with pulls & releases, and at the very highest peak I got out, jumped and pulled my parachute landing 5 days later!!)

So what I learned in my own personal case here is that sometimes the drug dictates the myasthenia, but at other times the myasthenia has a life of its own and the power of a spontaneous remission from long term fatigable weakness can at times silence even the most offensive of drugs.
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Old 08-26-2012, 01:33 PM #6
kathleenob kathleenob is offline
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Doing more research on myasthenia gravis. When this started over a year ago I kept mentioning to the Doctor's that I thought it was tied to taking clindamycin two weeks before. JUST found a list of medications to avoid that are implicated in either inducing or worsening myasthenia gravis. Yep, it is one of them. IGNORED for over a year. Oh yes, will bring up it this week at my appointment.
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Old 08-26-2012, 02:09 PM #7
hajile99 hajile99 is offline
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Thanks Anacrusis (and all). Hopefully I'll be able to get some sort of preliminary answers when I go to the neurologist, whether it turns out to be MG or something completely different. Although, I presume it will take a little time to get any sort of official diagnosis.

Kathleenob- Glad you were able to find the article. Hopefully it'll help you and you and your doctor will be able to find a solution!
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Old 08-27-2012, 01:57 AM #8
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Quote:
Originally Posted by hajile99 View Post
I guess I'm not trying to infer that the drug caused the disease, per se, but perhaps it had remained stagnant in my body (or perhaps manifesting in smaller, less noticeable ways that I may have ignored or just thought was "normal") and was brought out more substantially due to this medication. Again, this is all theoretical, to a degree, because I'm not entirely sure what's going on with my body.
Now that you've clarified the question, this is extremely possible. My neuro at the time suspected MG, but it was brought out by an anesthesia that caused me to stop breathing. There were signs of it earlier, but doctors were able to either ignore them or right them off as part of another disease.
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