Originally Posted by 4-eyes

You can now have a test for the JC virus prior to treatment. If you find that you test positive, then you would have to really think if you wanted to take the very small, yet potentially deadly risk. OTOH, Cellcept and even pred also carry the risk of JC virus reactivation, and I take both of them (which made me more reluctant to do the rituxan at the time).

All in all, it is more typical to do IVIG, plasmapharesis, oral steroids or an immune suppressing drug before going on the rituxan or cytoxan or high dose cytoxan (which I eventually did). Sounds like you need to do some research and either email or have a long talk with your neuro, to make sure you're on the same page.

Good luck.