At least I had one good day on Saturday, but I paid for it yesterday. My adult daughter wanted to go back to Walmart again, so I had to use one of the electric carts to get around. My muscles were weak again and I guess I did so much yesterday that the joint in my big toe was hurting making me limp. I tend to push myself to walk even though it's hard, but yesterday there was no way.

Maybe it's not the Mestinon dosage and maybe I just have to accept my limitations.

I've had MG for 30 years. Many years all I needed was 1/4 to 1/2 Mestinon to alleviate my symptons. At those times, taking 60 mg would cause me to overdose and increase my weakness. If you find that the 1/2 is a little too much (periods of inactivity), try 1/4.

You're right, I think I need to adjust the dosages. Not only am I having breathing trouble right now but my chin is drooping dramatically. I'm going to try and rest today instead of pushing myself. I haven't been resting like I should.

What I have always done is take the minimum - maybe 15 mg - then add 15 every 1/2 hour (that's how long it takes to work) until I feel better. Don't forget that too much makes you feel as weak as too little.

My muscles became weaker when I lowered the dose. Yesterday I tried going back to the full 60 mg dose, but every 4 hours. I did much better. I guess it wears off too fast and lowering it wasn't the right thing for me to do.

I saw the doctor today and he said that it was alright to take every four hours, but not to exceed 1500 mg. in a 24 hour period. He is going to put me on Imuran after some blood work -- a cbc and cmp, and he's sending me for a CT scan of my thymus.

Even though he's a Rheumatologist, he's doing a far greater job than any Neurologist I've seen. I think I'll keep going as long as he can help.

Good luck with the Imuran. I've been taking it for about 4 years. I've had some issues but overall it helps. If you need 60mg, take it on time. It sounds like you let it wear off and then it's hard to get feeling better again. My doctor tells me to never go more than 4 hours without 60mg.

Thank you all for your replies. Sorry I haven't responded, my eyes are blurry lately. I have a hard time reading anything. I've had a rough week because I had to move to another house. I wonder if I should up my dose even more when I do more work than normal.