Multiple antibodies

alice md · 01-24-2013, 03:27 AM

Quote:

Originally Posted by AnnieB3

Quandry, The immune system is complex and they still don't know everything about what treatments are best for exactly what kind of disease. Like Alice said, some treatments do work for some diseases or people but don't for others.

I think the important thing is to try to work with your neurologist to see what works best for you. Have you discussed IVIG?

Alice, I did a lot of research on this early on. Any of the IgG subclasses can be involved in MG. And I believe that is why some people might have a more mild course of the disease as opposed to others. I don't want to get into a long discussion here, for the sake of Quandry, but I had to bring this up.

http://www.ncbi.nlm.nih.gov/pubmed/3621677

http://brain.oxfordjournals.org/cont...ws025.abstract

https://openaccess.leidenuniv.nl/handle/1887/20412

http://books.google.com/books?id=V61...20IgG3&f=false

Annie,

Surprisingly, the role of IgG4 subclass antibodies has not been appreciated enough for many years, as they do not fix complement and do not lead to destruction. The understanding that antibodies can exert their effect by internalization and blocking of essential cellular pathways is relatively recent.

Even more so the understanding that this can lead to a much more severe (and not milder) course of the disease.

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