How much nsaids is too much? I take ibuprofen.

So sorry to hear that you are having this problem. I have a friend at work that said that his kidney problems are caused by an autoimmune issue.

As far as to why they will increase the mestinon dosage, it is most likely because the kidneys are what gets rid of your old mestinon. If you take as much as you used to, your blood levels may get to toxic levels.

"Renal Dysfunction
In anephric patients (n=4), the elimination half-life increased 3 fold and the systemic clearance
decreased by 75%. Therefore caution should be observed when administering pyridostigmine
bromide to patients with impaired renal function."

Source: http://www.fda.gov/downloads/Drugs/E.../UCM133154.pdf

(This was from the military use of the drug, but the mechanism is the same.)

THANK YOU! This makes perfect sense!

I don't know how much is too much. I was taking one 375 mg tablet 3 times per day. I've been on naproxen for 5 years. Last year all my kidney function tests were normal. My GFR was in the high 60s. This time my GFR was 23. Less than 15 requires dialysis or a transplant. Had I known of this danger I believe I would have insisted on narcotics, as crazy as that sounds.