FAQ/Help |
Calendar |
Search |
Today's Posts |
![]() |
|
Myasthenia Gravis For support and discussions on Myasthenia Gravis, Congenital Myasthenic Syndromes and LEMS. |
|
Thread Tools | Display Modes |
![]() |
#3 | ||
|
|||
Junior Member
|
Thank you for your brief look into the relation of HLA-B27 to MG. Yes it is more relating to AS (ankylosing spondylitis) which I also have thus my piqued interest. There is a stronger relation of MG to HLA-B8, however in late onset of MG in Males (age 60-80) there is an association with HLA-B27.
http://eyewiki.aao.org/Myasthenia_Gravis "The disease has a bimodal pattern, having an early peak in the second and third decade, and a late peak in the sixth to eighth decade. The early peak shows a female predominance, approximately 3:1, and an association with HLA-B8, HLA-DR3, and HLA-DR1, the latter being more specific for ocular MG. Interestingly, the late peak features a male predominance and an association with HLA-B27 and HLA-DR2" This is another good link to the dysfunction of the T cell and the genetic link to MG: http://europepmc.org/backend/ptpmcre...8&blobtype=pdf |
||
![]() |
![]() |
"Thanks for this!" says: | kiwi33 (12-05-2015) |
|
|