My neuro is wanting to start me on this. Anyone care to share their experience with it?

I took Methotrexate in the past for awhile, but not for MG. I also have rheumatoid arthritis, so I took it for that. This may not be a particularly helpful post, but I see you have had no responses thus far.

The main thing I can tell you is to be sure to follow up on any blood tests that your doctor recommends that you should do. Everyone is different, but I was not able to tolerate Methotrexate over the long-term due to problems with liver function. Many people tolerate it just fine, but it's important to check your liver function with blood tests regularly.

I hope you'll do well with it, and it will be helpful for you. I send lots of good wishes your way!

Take care,
Erin

I took methotrexate in the past too, before I was diagnosed with MG. I took it for colitis. I could not tolerate the pills, they caused too much nausea and a feeling of flu symptoms for a day after the weekly dose. I moved on to doing a sub Q shot once a week. I didn't have any negative side affects with that. It really helped the inflammation and pain I was having. It took a little getting used to in order to do the shot, but it does help you in the end.
I hope this information is helpful.

Thank you for the responses. I have damage to my intestines from radiation and was wondering about how hard methotrexate is on the stomach. I have a hard time with mestinon for this reason. He has introduced Levsin into my pill rotation to hopefully help out.