In my wanderings, I happened to visit and stay in a village that was concerned with and devoted to the aiding of those with leprosy. One person who I became quite close to, was helping me to open my door. The key was perhaps not fitting the lock and she just put all her force in the twisting of the key. The door opened, but in looking at her index finger, it was cut to the bone. She did not feel it. It is good to have some signal that the organism is being harmed. It is when the signal keeps on, intensifies once harm has been removed, that becomes a problem. It is a conundrum. DOWTONg