Parkinson's Disease Tulip


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Old 10-17-2009, 08:34 PM #1
lurkingforacure lurkingforacure is offline
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Default What? Scientists remove beta-amyloid plaques from live animal brain

Here's the link...if I am reading this right, the activated microglia made things better? This doesn't reconcile with most of what I have read to date, that the activated microglia cause problems...http://www.sciencedaily.com/releases...1015091602.htm
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Old 10-18-2009, 05:39 AM #2
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Quote:
Originally Posted by lurkingforacure View Post
Here's the link...if I am reading this right, the activated microglia made things better? This doesn't reconcile with most of what I have read to date, that the activated microglia cause problems...http://www.sciencedaily.com/releases...1015091602.htm
The difference is in the two diseases, I think. The problem with microglia in PD is that they don't turn off. In the study they were intentionally turned on and attacked the plaque. I use the analogy of teenage boys with nothing to do vs the same boys with a purpose:

"This is in contract to PD where the same cells when chronically activated have no plaques to target. Like a bunch of teenage rowdies unemployed and hanging out on the street corner, they degrade the whole neighborhood due to a lack of focus. Rumors of threats from surrounding neighborhoods keep tensions high even though they don’t materialize. Give them the needed focus, cleaning the junk off the local basketball court for example, and they improve things they would otherwise have degraded." More...
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Born in 1953, 1st symptoms and misdiagnosed as essential tremor in 1992. Dx with PD in 2000.
Currently (2011) taking 200/50 Sinemet CR 8 times a day + 10/100 Sinemet 3 times a day. Functional 90% of waking day but fragile. Failure at exercise but still trying. Constantly experimenting. Beta blocker and ACE inhibitor at present. Currently (01/2013) taking ldopa/carbadopa 200/50 CR six times a day + 10/100 form 3 times daily. Functional 90% of day. Update 04/2013: L/C 200/50 8x; Beta Blocker; ACE Inhib; Ginger; Turmeric; Creatine; Magnesium; Potassium. Doing well.
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