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12-29-2009, 12:20 PM | #31 | ||
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In Remembrance
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Quote:
thanks, paula
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paula "Time is not neutral for those who have pd or for those who will get it." |
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12-29-2009, 03:46 PM | #32 | |||
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Senior Member
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Paula,
Glad you're experiencing less dystonia. I don't have it often, just in my foot sometimes but when I do....yowsa! I ran across this abstract that does a great job in summing up the various parts of the brain impacted by PD and also links them to the various symptoms we experience. For example, "...postural-gait disturbances are due to lesions in gait control systems including basal ganglia, pedunculopontine nucleus and frontal lobe." I'm guessing this is why levodopa does not provide much relief here. Maybe I'll reformat this info into a table and make a sticky- I think it would be a useful reference. http://linkinghub.elsevier.com/retri...53802006001040 Laura |
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"Thanks for this!" says: |
12-29-2009, 07:31 PM | #33 | ||
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In Remembrance
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so a new pathway into the more serious research highways, those having PIgD [don't know spelling yet] postural and gait disturbances are more likely to fall and get dementia. I think dementia for PD is in need of much attention. I do fear it has not been given enough ; these drugs are pretty strong and we try to do as much as we can.....sometimes. lol But we are not normal. I wrote to someone my inner mess keeps leaking out.
if one doesn't factor moody or well..i really wish it would be changed from 'Parkinson Personality" What an insult! I doth protest. But if you don't factor it in, you are taking advantage of us. Do we need dementia definitions updated ? I don't know who i am t alking to .....just whoever and nicely
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paula "Time is not neutral for those who have pd or for those who will get it." |
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12-30-2009, 12:45 AM | #34 | |||
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Senior Member
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Quote:
I just ran across this abstract: Parkinson's disease (PD) is traditionally viewed as a mainly hypodopaminergic syndrome, with symptoms resulting predominantly from loss of dopamine-producing neurons in the substantia nigra. However, while most of the cardinal motor features of PD respond well to dopaminergic therapy, many other features of the disease do not. Balance impairment and the associated risk of falling represent one of the most prominent and potentially disabling features that are typically refractory to dopaminergic treatment. Therefore, it is possible that lesions in nondopaminergic systems contribute to the pathophysiology of postural instability in PD. Such nondopaminergic lesions are well recognized, certainly in advanced stages of PD where postural instability and falls dominate the clinical presentation. However, it remains unclear which of the identified nondopaminergic lesions is specifically responsible for postural instability and balance impairment. In this review, we argue that cell loss in the locus coeruleus and a resultant central norepinephrine deficit are intimately involved in the pathophysiology of postural instability in PD. If proven to be correct, this link between defective noradrenergic neurotransmission and postural instability could have important implications for the future development of new symptomatic treatments aimed to correct postural instability and preventing falls. Studies in the next 5 years could test this hypothesis, using a battery of complementary research techniques, including advanced neuroimaging (structural, functional imaging and nuclear), neurochemical studies of cerebrospinal fluid, post-mortem clinicopathological analyses and detailed clinical balance evaluations supplemented by posturography studies. Postural instability in Parkinson's disease: the adrenergic hypothesis and the locus coeruleus Authors: Grimbergen, Yvette AM1; Langston, J William; Roos, Raymund AC; Bloem, Bastiaan R Source: Expert Review of Neurotherapeutics, Volume 9, Number 2, February 2009 , pp. 279-290(12) Publisher: Expert Reviews http://www.ingentaconnect.com/conten...00002/art00013 One researcher I read wondered why it is that only the dopaminergic responsive symptoms of PD are treated when they largely are NOT the ones that ultimately disable when the ones that do like freezing and falling have no targeted treatments? Why? Take a look at PDOR- the term 'noradrenergic' occurs 6 times! On the plus side, the drug fipamezole is undergoing clinical trials for use in PD. I suspect one reason more drug research isn't going on here has to do with more money being thrown at the familiar dopa therapies- we need to move beyond just seeing dopamine replacement as a panacea. |
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12-30-2009, 08:53 AM | #35 | ||
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In Remembrance
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Going out till later on......great find Laura. Looking at all the transmitters is very important and I'm glad the emaphsis is shifting to the balance [no pun intended] of them all.
Nortriptyline also helps dyskinesia by the way. paula
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paula "Time is not neutral for those who have pd or for those who will get it." |
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12-30-2009, 09:34 AM | #36 | |||
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Member aka Dianna Wood
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Sounds Like you and I are in the same stage, except the panic attacks and depression. Acceptance would account for that on my part. For your shortness of breath, I have found a nebulizer and an inhaler to be helpful. I suspect the bronchial passages are affected by the PD and the nebulizer relaxes the bronchial passages. At first you will feel like putting a paper bag over your head as the oxygen rush will make you dizzy and lightheaded. But give it time and use regularly, and your breathing will begin to supply your body with the oxygen you have been craving so long.
Good Luck and thanks for bringing up such a fascinating thread, |
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"Thanks for this!" says: | paula_w (12-31-2009), ZucchiniFlower (01-04-2010) |
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