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01-27-2010, 11:45 AM
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Brain Res Mol Brain Res. 2002 Dec;108(1-2):143-6.
1,25-Dihydroxyvitamin D(3) increases striatal GDNF mRNA and protein expression in adult rats. Sanchez B, Lopez-Martin E, Segura C, Labandeira-Garcia JL, Perez-Fernandez R. Department of Physiology, School of Medicine, University of Santiago de Compostela, Spain. Glial cell line-derived neurotrophic factor (GDNF) has been postulated as a possible candidate for therapeutic treatment in Parkinson's disease (PD). Recent in vitro data suggest that 1,25-dihydroxyvitamin D3 [1,25(OH)(2)D(3)] treatment may enhance GDNF mRNA expression. In the present study, using semiquantitative RT-PCR and Western blot, we have shown that 1,25(OH)(2)D(3) administration intraperitoneally, significantly increases GDNF mRNA and protein levels in the striatum of adult rats. PMID: 12480187 [PubMed - indexed for MEDLINE] http://www.ncbi.nlm.nih.gov/pubmed/12480187
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In the last analysis, we see only what we are ready to see, what we have been taught to see. We eliminate and ignore everything that is not a part of our prejudices. ~ Jean-Martin Charcot The future is already here — it's just not very evenly distributed. William Gibson |
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| "Thanks for this!" says: | mrsD (01-27-2010) |
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01-27-2010, 01:36 PM
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In Remembrance
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It is interesting to note that people in the higher latitudes get less sunlight, have less vit D, and have more PD.
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Born in 1953, 1st symptoms and misdiagnosed as essential tremor in 1992. Dx with PD in 2000. Currently (2011) taking 200/50 Sinemet CR 8 times a day + 10/100 Sinemet 3 times a day. Functional 90% of waking day but fragile. Failure at exercise but still trying. Constantly experimenting. Beta blocker and ACE inhibitor at present. Currently (01/2013) taking ldopa/carbadopa 200/50 CR six times a day + 10/100 form 3 times daily. Functional 90% of day. Update 04/2013: L/C 200/50 8x; Beta Blocker; ACE Inhib; Ginger; Turmeric; Creatine; Magnesium; Potassium. Doing well. |
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01-27-2010, 07:46 PM
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#3 | ||
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Quote:
http://www.eurekalert.org/pub_releas...-upr012710.php |
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In animal model, VitD3 increased GDNF mRNA levels in striatum
Linear Mode
