I had once read a report saying that the progress of PD cannot be reasonably predict except that scientist almost came to agree the following phenomena:

1. male PD appears to progress faster
2. tremor-dominated PD appears to progress slower

Is there any other factors that can reasonably predict the progress? would any of you kindly share your view/ experience?

In my case, I was diagnosed in 2001 when I was 36. PD progressed mildly in the first 3 years after the diagnosis and I managed to control the syptoms by only taking low dosage of selegiline and then Requip. However the situation started to run downhill in the last couple of years and I am puzzling if I have done anything wrong with the treatment of the disease. I am currently taking 3 dosages of Stalevo (each with 100 mg Levedopa) a day and 200mg CoQ 10. I know I am a bit undermedicated. Thanks

and, as you can see from our discussion here, causes are still very much uo in the air.

However, and speaking strictly for myself, I have come to focus on the *processes* at work regardless of their causes, which can be multiple and quite maddening. In particular, any causes that I can intervene in. There are at least three or four.

Inflammation- opens the blood brain barrier, disrupts body chemistry, and a host of other effects. Any number of anti-inflammatories available from curcumin to aspirin, but do your research.

Microglial Activation- Immune system runs amok in our brain. Some things calm it down, green tea extract for one.

Stress- Our neuroendocrine systems are terribly out of whack and stress pumps out chemicals that we can no longer handle. De-stress in every way possible.

rick