Hi Ann,
I don't have RLS but I do have PD. I thought this may be of some help to you. At one point in the medication change game, I switched from Requip to Mirapex. I titrated down off of Requip completely before starting Mirapex. My reason for switching between Requip and Mirapex, weight gain, constant sleepiness, and cloudy thinking. Any positives from changing? No,none. Any negatives from changing? Yes, sleepiness became worse, weight gain became worse, cloudy thinking became worse, OCD urges grew significantly. I finally titrated down off of Mirapex and have never taken either again.

GregD

I also have RLS. The l-dopa alone seems to have taken care of it.

Ann - I take Requip (generic) for RLS. I took Mirapex years ago - first PD drug prescribed to me; after 6 years, switched to Requip because Mirapex made me sleepy.

That was five years ago. I decided to go off the Requip as well, because I don't like the way agonists make me think and feel, but, because of the RLS, I started up again with Requip about 3 years ago. I am taking the generic now; very low dose - 1 mg/ 3 times a day. Works well for my RLS - I also am taking Sinemet (generic) 3/day and Amantadine 3/day. That, plus an antidepressant, is my total med regimen.