I received an email from a Tom Musgrove, who has just written a book on the BBB theory, saying,

"Hi Ron,
just thought you'd like to know that you were right about tight junction leakiness being involved. I solved all of the neurological disorders with a tight junction permeability theory of disease,

I didn't encounter your theory of tight junction related to parkinson's till after I'd already developed my theory.
Here is the dime tour of my complete theory"

"The core of the theory is that damage/dysfunction of the tight junctions of the blood brain barrier (and other tight junctions such as those surrounding innervation to organs) results in nutrients that are actively transported across the BBB 'leaking out' of the Interstitial Fluid (ISF) back to the blood. This includes many components needed for the synthesis of of key neurotransmitters (particularly L-DOPA/dopamine/epinephrine/norepinephrine the 'dopamine path' and melatonin/serotonin + creatine/adenosine path) mylenation
(biotin) and protection/repair of oxidative damage (Glutathione). This results in a biosynthesis path deficiency which is often comorbid with a blood deficiency of the relevant nutrients. The pattern of and intensity of the damage (as well as timing) and degree of deficiency determines the particular neurological disease and pathology encountered.


His book is at

http://www.amazon.com/Junction-Perme.../dp/B005BU9VZO

I have been posting about the idea of a damaged Blood brain barrier for many years. Whether this author is correct in saying he did not see my posts until after he developed the theory, we will never know. At least my posts predate his book. He says,
"It might take more than a year for me to get my Nobel prize, how annoying".
I am not interested in recognition or Nobel prizes, I posted openly in the hope that more research would be done on the theory of a defective BBB. At least his book will add to the call for research in this area.
Ron

Ron,
what is a tight junction?

thanks

Hi Paula,
Here are a few definitions from Google. I vcan't give a more simple version, but maybe some of the others can. Girija?
I have always thought of it as a point in the BBB where transport in and out of the BBB takes place, but I am probably not accurate.
Ron


tight junc·tion


Tight junctions, or zonula occludens, are the closely associated areas of two cells whose membranes join together forming a virtually impermeable barrier to fluid. It is a type of junctional complex present only in vertebrates. .... More »

en.wikipedia.org/wiki/Tight_junction Source

Wikipedia - Answers.com




Tight junction: Definition from Answers.com




www.answers.com/topic/tight-junction - Cached
tight junction ( ¦tīt ′jəŋkshən ) ( cell and molecular biology ) An intercellular junction composed of a series of fusions of the junctional.

Structure - Functions - Classification - See also




tight junction : Definition




http://www.everythingbio.com/glos/de...tight+junction - Cached
Definition of tight junction : A multifunctional complex that forms a seal between adjacent epithelial cells, preventing the passage of most dissolved ...

Hi Ron,

Actually my search history is stored via google so it is perfectly feasible to find out for sure.

I didn't see your posts till the end of my research because I was searching primarily Pubmed and google scholar (from what I can tell you have one paper on the topic and it isn't one that would be encountered readily with the relevant search terms) and the cluster of diseases I was looking at first were autism, epilepsy, and tourette's syndrome and other diseases that cluster well with autism. I encountered your work once I started using regular google to expand lists of things that were related to tight junction permeability.

Heck even searching for - ron hutton tight junction - it is the 6th result and it isn't obvious that the link would provide anything of use. And going to the link from the first sentence it shows that you thought it was 'toxins leaking in' which by 2006 had already been proposed by numerous others.

Note that in 2003 we have

"Is Breakdown of the Blood-Brain Barrier Responsible for Lacunar Stroke, Leukoaraiosis, and Dementia?'

**

And there are sources much earlier than that

How about 1993

**

**

I'd be surprised if there aren't much older references than that (Alas prior to 1983 google scholar becomes rather useless). **

sorry LetterRIP but the system is programmed to block all types of link attempts by new members until they have the required number of posts.

Please do not attempt more links as they will be automatically blocked. We cannot make exceptions to this rule as that is how the anti-spam software is programmed

Okay, here is the same post but without links - you will have to google them yourself but I've provide the title, authors and date so should be easy.

Hi Ron,

Actually my search history is stored via google so it is perfectly feasible to find out for sure.

I didn't see your posts till the end of my research because I was searching primarily Pubmed and google scholar (from what I can tell you have one paper on the topic and it isn't one that would be encountered readily with the relevant search terms) and the cluster of diseases I was looking at first were autism, epilepsy, and tourette's syndrome and other diseases that cluster well with autism. I encountered your work once I started using regular google to expand lists of things that were related to tight junction permeability.

Heck even searching for - ron hutton tight junction - it is the 6th result and it isn't obvious that the link would provide anything of use. And going to the link from the first sentence it shows that you thought it was 'toxins leaking in' which by 2006 had already been proposed by numerous others.

Note that in 2003 we have

"Is Breakdown of the Blood-Brain Barrier Responsible for Lacunar Stroke, Leukoaraiosis, and Dementia?'

J.M. Wardlaw, FRCR, FRCP, MD; P.A.G. Sandercock, FRCP, MD; M.S. Dennis, FRCP, MD; J. Starr, FRCPEd, MD 2003

And there are sources much earlier than that

How about 1993 "Cerebral white matter changes in acquired immunodeficiency syndrome dementia: Alterations of the blood-brain barrier"
Christopher Power MD1, Pei-Ann Kong BSc1, Thomas O. Crawford MD1,2, Steven Wesselingh BMBS, PhD1, Jonathan D. Glass MD1,3, Justin C. McArthur MBBS, MPH1, Dr. Bruce D. Trapp PhD. 1993

How about 1983 "The primary lesion in Alzheimer's disease and dialysis dementia has been postulated to be an impaired blood-brain-barrier (BBB) permeability that allows neurotoxins like aluminium to reach the central nervous system. The present study shows that aluminium itself affects the permeability of the BBB of rats to small peptides. Intraperitoneal injection of aluminium chloride increased the permeability of the BBB to iodinated N-Tyr-delta-sleep-inducing peptide and β-endorphin by 60-70%. Thus, aluminium can affect the BBB in ways that might be involved in dementia." Williama. Banks, Abbaj. Kastin 1983

I'd be surprised if there aren't much older references than that (Alas prior to 1983 google scholar becomes rather useless).

Ron also published his theory in PD Online Research which for us was quite a big deal given as patients we are not in the loop. This was two years ago, I think; I'm sure Ron can confirm.

This brings to mind...when do people turn to PD Online Research as a resource?
I turn to it when I know there is an aspect of PD has been understudied or to see if there is new life for research that seemingly got sucked into the Valley of Death.

Ron's news is an example of how far we have progressed with the idea of translational research...

Laura

In fact, I believe I am a part author of the BBB theory, and only realised I had said "my"theory. I tried to edit it, but there was no edit function days later. It is clear I don't regard myself as sole author of this theory when my posts quote so much of the prior art.
The contributions I hve made which had not been proposed before, are points such as the fact that virtually every substance or treatment which is reported to improve symptoms, reduces the poroscity of the BBB..
Treatments that open the BBB exacerbate symptoms.
Although it is known stress causes a freeze, THere was no adequate explanation why. My contribution was to propose that a freeze was due to the opening of the BBB, and either loss of dopamine to the bloodstream, or influx of toxins from the bloodstream. I have not found any prior litrerature which suggested there could be a reverse flow of dopamine to the bloodstream.
I have posted regularly on Neurotalk, and its predecessor Braintalk over the years, but I don't think we can access Braintalk any more. I have written to many companies and institutes to try to persuade them that this was a fertile area for research.
The bottom line is what is the new and novel information disclosed in this book. With so much prior art, whai is the patent based on?
The BBB theory is a much ignored line of research, and I welcome any attempt to punlicise it, but Tom can't point out all the prior art and say I can't claim to be the author,which I accept, since I have quoted it myself, then come along years afterwards and claim he is the author. We don't want to argue between ourselves. It is a waste of our resources. We should poole our lobbying efforts and get more research done in this area.
Ron

I can acknowledge that you have ascribed to the BBB theory years ago. I will try to access BrainTalk and show that you wrote about it a long, long time ago.

Ron quoted here (earlier in this thread): I am not interested in recognition or Nobel prizes, I posted openly in the hope that more research would be done on the theory of a defective BBB.

This is one example of your humbleness, Ron. You're not "IN IT TO WIN IT;" YOU'RE "IN IT TO BEAT IT!"

Thanks for all you do.
Peg

I solved all of the neurological disorders with a tight junction permeability theory of disease,

I didn't encounter your theory of tight junction related to parkinson's till after I'd already developed my theory.

Looking forward to an imminent cessation of all neurological disorders then - solution found

solve: resolve, answer, work out, find a solution to, find the key to, puzzle out, fathom, decipher, decode, clear up, straighten out, get to the bottom of, unravel, piece together, explain; informal figure out, crack.

theory:hypothesis, thesis, conjecture, supposition, speculation, postulation, postulate, proposition, premise, surmise, assumption, presupposition; opinion, view, belief, contention.

Personal belief - we are so connected as human beings that we cannot claim to have truly original thought, just the light bulb moments, when we have synthesized all the things we have learned before...... mostly at the feet of other people......

PS Search engines of all kinds do not always turn up the most relevant link first..........

Ron, it will always be 'your' theory, much discussed among us PD'ers for many years. Suggest that this gentleman's ideas, with a start point of autism, are a theory among many others. Remember many posts here and on the old forum on opening the BBB in reference allowing novel treatments in, too, and what is and isn't possible.... Great discussions all.......thanks