Tonya-
With the attacks that I am talking about my BP would swing that low. How high does yours go at the worst time? And what effect is there onyour "offs" if you skip lunch?
-Rick

Reverett,
At my worst time the BP is around 97/63 and pulse around 75 or more. If I skip lunch, off times seem to be worse. Puzzled about neuropathy. When meds work, I don't have it at all.

Thanks for the help.
Tonya

Possible Hypotension?

having a pretty bad "off" time now. just took BP
107/69 pulse 86

Sorry, I should put these concerns and questions on a visitor's message.
I definitely don't want a big audience.

Please proceed with the subject at hand - Perindopril Test.

Thank you, Rick

Tonya

Sorry that I have been letting this thread slip and I will try to bring it a little more up to date. I continue to be both leased and hopeful with the perindopril. No miracles but, instead, a sense of steady improvement. I keep tinkering with dosage and so on. This, in turn, is a little messy. But, heck, if you want tidy go out and buy a gerbil!

Earlier this evening, my wife mentioned that it has been a great relief to once again have my help around the house! Once she pointed it out I could see that, once I quit messing with times and dosages, there was an unmistakable improvement overall. I will do better on keeping this updated.

Of the three ACE inhibitors only trandopril (Mavik) is available in the US.
It is not commonly prescribed, though. The most common side effect of
drugs in this class is a cough. Rarely, they cause angioedema which can be fatal.

GerryW-
Wikipedia lists 14 individual ACEIs. They don't say which are not available in the US. I know that at least one is available (i.e. perindopril). So somewhere between the two. -Rick

I would like to remind here, that not ACE inhibitors cross the blood brain barrier well or at all. I have a post above that
has a link about that.

""ACE inhibitors that cross the blood-brain barrier reduce cognitive decline by 50% compared [with] the decline seen in people on other blood pressure medications," presenter and lead author Kaycee M. Sink, MD, MAS, an assistant professor of internal medicine in gerontology at Wake Forest University School of Medicine in Winston-Salem, North Carolina, told Medscape.

Centrally active ACEIs, such as captropril (Capoten), fosinopril (Monopril), lisinopril (Prinivil or Zestril), perindopril (Aceon), ramipril (Altace), and trandolapril (Mavik), cross the blood-brain barrier. Previous animal studies suggest that centrally active ACEIs protect against dementia not only by controlling hypertension, but also by decreasing oxidative stress and reducing inflammation in the brain.

"Treating blood pressure may be about more than just getting blood pressure to a certain target," Dr. Sink said. "Which drug we use may have implications beyond blood pressure control, like reducing risk of cognitive decline. High blood pressure is a risk factor for dementia, so it is important to know if the type of blood pressure medicine a person takes can cut that risk."

http://www.medscape.com/viewarticle/556014

Rick,

As you know, I experience attacks very similar to yours. I am trying to understand how I have weakness, can barely walk, or speak, yet have a spike in blood pressure. I am normally at 109/80 and yesterday at height of a mild attack it was at 153/100 which scared the heck out of me. If my doctor does not address I honestly feel like I will not make it another five years. This feels so taxing on my system and I know must exacerbate, if not accelerate PD.

I am trying to narrow down whether it is my aldosterone levels, simply a side effect of levodopa, or a primary kidney dysfunction. I was hospitalized three years ago during my pregnancy for a pretty intense kidney infection. So I'd say I am having symptoms of renal tubular acidosis and/or diabetes insipidus as well as the renin-angiotensin deal.

Is polyuria a key element of the aldosterone overload? Does this result in too much sodium in our bloodstream and low potassium? Or do we lose both sodium and potassium through large volumes of urine. I can say I am urinating out way more liquid than I take in, feel parched/dehydrated most of the time, yet at the sam time crave salt. I get the blood pressure spike during an attack then normalize within minutes of urinating.

Sorry to be so graphic...TMI for most. Normally, I'd PM you but I suspect there are many more off us going through this, so doing my part to hopefully help others.

Thanks!

Laura