[CarolynS]

Overall sales in PD drug market to decrease slightly by 2020

InfoGrokPharma (UK) Friday, 21 October 2011

Overall sales in Parkinson’s disease (PD) drug market will decrease slightly from $2.7 billion in 2010 to $2.6 billion in 2020 in the US, France, Germany, Italy, Spain, the UK and Japan, according to findings from Decision Resources.

Despite some key current therapies experiencing increased uptake during the forecast period and the launch of three new agents by 2020, sales of current agents and the market impact of emerging therapies will be offset by generic competition.

The three emerging therapies set to launch through 2020 are Impax Laboratories/GSK’s IPX-066, a reformulation of the mainstay of PD therapy, levodopa (multiple brands, generics), Merck Serono/EMD Serono/Newron’s MAO-B inhibitor safinamide and Kyowa Hakko Kirin’s adenosine A2A receptor antagonist istradefylline. IPX-066, and to a lesser extent safinamide, will contribute moderately to market growth, as both will contend with established agents within the same respective drug classes (which are often generically available), and that are commonly used in the patient populations targeted by the emerging therapies.

The first-in-class agent istradefylline will benefit from use in the management of motor response complications arising from levodopa treatment, but its overall impact will be modest as it is currently expected to launch only in Japan.

[paula_w]

Originally Posted by digger

Overall sales in PD drug market to decrease slightly by 2020

InfoGrokPharma (UK) Friday, 21 October 2011

Overall sales in Parkinson’s disease (PD) drug market will decrease slightly from $2.7 billion in 2010 to $2.6 billion in 2020 in the US, France, Germany, Italy, Spain, the UK and Japan, according to findings from Decision Resources.

Despite some key current therapies experiencing increased uptake during the forecast period and the launch of three new agents by 2020, sales of current agents and the market impact of emerging therapies will be offset by generic competition.

The three emerging therapies set to launch through 2020 are Impax Laboratories/GSK’s IPX-066, a reformulation of the mainstay of PD therapy, levodopa (multiple brands, generics), Merck Serono/EMD Serono/Newron’s MAO-B inhibitor safinamide and Kyowa Hakko Kirin’s adenosine A2A receptor antagonist istradefylline. IPX-066, and to a lesser extent safinamide, will contribute moderately to market growth, as both will contend with established agents within the same respective drug classes (which are often generically available), and that are commonly used in the patient populations targeted by the emerging therapies.

The first-in-class agent istradefylline will benefit from use in the management of motor response complications arising from levodopa treatment, but its overall impact will be modest as it is currently expected to launch only in Japan.

pharmacies would be scrambling for pd drugs if they found a way to replace the cells. An opinion explained to me by a PT and it makes sense. the problem is the infighting.....and everyone wanting their own way. they need to dig deep and find out whether we have our own capability.

For all the alternative, anti chemical thought today - not just here but all over, why would we want to mix peoples cells? Ten years from now, we might discover...oops the cells aren't as blank as we thought,

we must just DO IT. obviously my generation missed the boat. Actually the boat hasn't sailed yet...isn't even built. maybe we should go underground....

[lurkingforacure]

Originally Posted by paula_w

pharmacies would be scrambling for pd drugs if they found a way to replace the cells. An opinion explained to me by a PT and it makes sense. the problem is the infighting.....and everyone wanting their own way. they need to dig deep and find out whether we have our own capability.

For all the alternative, anti chemical thought today - not just here but all over, why would we want to mix peoples cells? Ten years from now, we might discover...oops the cells aren't as blank as we thought,

we must just DO IT. obviously my generation missed the boat. Actually the boat hasn't sailed yet...isn't even built. maybe we should go underground....

Thanks for this Paula, I'm not clear, though, on what you mean by mixing cells...do you mean mixing cells from one person with those of another (a bad idea IMHO) or taking one's own cells and somehow mixing them? I'm all for that, actually, and if we found out in ten years that there were things with doing that that were actually not so good, well, that PWP who mixed his cells within himself would have had ten years (or more) of relief from this damn disease, hopefully, and doesn't that happen with drugs out there all the time now anyway? New drug comes out, sounds great, oops, we learn later that it gives people heart attacks...or worse.

Until something comes along, like you said, that seriously cuts into the so-lucrative-there's-no-incentive-to-develop-anything-else drugs, nothing will move forward. I'm also very much interested in Jannetta's theory of vascular compression in PD, which would have enormous impact if shown to be beneficial for even a small percentage of PWP.

[paula_w]

i meant using our own cells -for our own treatment. not anyone else's cells. Can we avoid immune problems that way and save time?
I like the hopefulness of the vascular compression , some don't seem to be impressed.

[imark3000]

Paula said: "they need to dig deep and find out whether we have our own capability. "
First of all, I am so happy that you are back stronger on bashing on the medical establishment!
IMHO the dopamine replacement/enhancement therapy has reached it's limits and the numerous new drugs did not make a big difference since the discovery of l-dopa/carbodopa.
The only break through in my opinion was DBS, which holds promise if it is refined and developed to non invasive version by avoiding the necessity to drill holes in the brain and I remember that some research was conducted with externally stimulating the peripheral nerves.
The other thing I believe in is what Paula said "they need to dig deep and find out whether we have our own capability" to self heal and helping our brains to compensate.
God bless