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Senior Member
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We have two active threads which describe very promising research results.
Forced exercise shows " ... blinded UPDRS-III [motor section] ratings improved by 35% from baseline to EOT for the FE group" [1]. Bio-feedback shows "37% improvement of the motor scale of the Unified Parkinson's Disease Rating Scale" [2]. I'm struck by the closeness (35% and 37%) of the results. This closeness is not statistically significant (about 1 in 20 pairs of integer values drawn randomly from the range 0 to 100 would be at least as close). But, nevertheless, it makes me think: is it coincidence? Could it be that both approaches address the same underlying process? Could it be that the UPDRS does not provide the necessary level of linear accuracy in this case? [1] "It Is Not About the Bike, It Is About the Pedaling Forced Exercise and Parkinson's Disease" Jay L. Alberts; Susan M. Linder; Amanda L. Penko; Mark J. Lowe1; Micheal Phillips Exerc Sport Sci Rev. 2011;39(4):177-186. http://www.medscape.com/viewarticle/751998 [2] "Real-time functional magnetic resonance imaging neurofeedback for treatment of Parkinson's disease." Subramanian L, Hindle JV, Johnston S, Roberts MV, Husain M, Goebel R, Linden D. J Neurosci. 2011 Nov 9;31(45):16309-17. (From abstract, http://www.ncbi.nlm.nih.gov/pubmed/22072682 the paper itself appears to be behind a pay wall.) John
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Born 1955. Diagnosed PD 2005. Meds 2010-Nov 2016: Stalevo(75 mg) x 4, ropinirole xl 16 mg, rasagiline 1 mg Current meds: Stalevo(75 mg) x 5, ropinirole xl 8 mg, rasagiline 1 mg |
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"Thanks for this!" says: | Conductor71 (11-18-2011), imark3000 (11-16-2011) |
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