[olsen]

bad stress tied to inflammation

http://www.sciencenewsdigital.org/sc...e.action?pg=11

[ol'cs]

and all inflammatory responses are autoimmune responses. cs

[jcitron]

Originally Posted by ol'cs

and all inflammatory responses are autoimmune responses. cs

I can vouch for this. Stress from work has actually made my PD worse. Now my medication no longer works properly. This was after 6 years of successful Sinemet and Amantadine use. Now I get nauseated only when taking the medication!

Yesterday I had a long talk with my manager's manager. He's visiting from Redwood Shores and we spoke at length about what's happening. He said not to worry and he'd ensure that what's been happing won't happen again to either of us. There's one other IT guy in my group and we handle nearly 650 people in the local building and no field people. So perhaps things will settle down again, and I can get back on track. I doubt it though because once the damage is done, it's a sealed fate. I have yet to recover from everything that happened a two weeks ago.

John

[reverett123]

http://amatterofbalance.wordpress.com/

Discussing the Science of Parkinson's Disease

Home
0 – Start Here
1 – Preface
2 – Introduction
3 – Contents
4 – Appendix
5 – A Possible Solution
6 – A Last Word
Critical Events/Times
External Factors
Interacting Systems
Internal Factors
Miscellany
Self-Destructive Processes

Parkinson’s Disease, Stress, and Inflammation
May 13, 2011

A report in this morning’s Science Daily News started a cascade of its own as several pieces of the puzzle clicked into place. With the charming title of

“Seeing Family for the Holidays? Scientists Discover How the Stress Might Kill You”

It goes on to state “”…. researchers from the University of Connecticut Health Center have found that the same part of our nervous system that is responsible for the fight-or-flight response (called the sympathetic nervous system) also controls regulatory T cells, which are used by the body to end an immune response once a foreign invader has been removed or destroyed.”

So, here is a link between the endocrine system’s fight or flight response and the immune system’s method of ending an immune response (which fails in the case of PD) with the nervous system’s sympathetic division being responsible for both. Is it possible that events impacting the endocrine stress system could act upon the sympathetic nervous system in such a way as to impinge upon its ability to end an immune response that is no longer needed,,,,


,,,MID: 19619638 [PubMed - indexed for MEDLINE]

So here we have T cells, essential for communication of stand down orders within the immune system, suffering a 50% reduction in population due to trauma. If the unfortunate individual was one with an unusual sensitivity to bacterial toxin LPS due to early life events and was barely able to control the microglia anyway, what does a loss of half his communication ability do?

And what does this say about the rather large sub-group of PWP who report unusually traumatic childhoods? If they had also experienced LPS hypersensitivity, would they not have a similar problem?

Stress (trauma) reduces the ability of the sympathetic nervous system to regulate immune response which, in turn, allows the runaway microglial activation that ultimately damages the substantia nigra and reduces motor symptoms.

*******************************

I posted the above just over a year ago to my blog, "A Matter of Balance" shortly before my life went all to hell and damn near killed me. In the process I learned a lot - far too much to cover here in any detail so, if you are interested visit AMOB and return here for discussion.

[maryfrances]

What happened? Can we learn from it?

How can we reduce our stress? Especially,
if we are still working?

My doctor did tell me at my last visit that
I would be better if I wasn't working. My
job is very tough. Teaching little ones all
day.

How do you spell stress? "MY LIFE"
It has been crazy! I got divorced. I
remarried. Things were very difficult.
I can really see the decline over the last
few years. I look older, feel worse, etc.
PD has taken its toll on me.

Any suggestions?