My wife takes her last dose of Sinemet and Comtan at 10:30 PM right before she goes to bed. She will often need to get up 2 or 3 times to go to the bathroom. By the time 2 or 3 AM rolls around, she is too stiff to get out of bed herself and needs my assistance. She takes her first dose of the next day at 7AM. By that time she is extremely stiff and basically can't move at all without assistance.

She has tried Sinemet CR and it was totally worthless! I know that Impax and GSK will soon be launching a new long-acting Sinemet which is appears to be the first really long-acting Sinemet. Far more effective than Sinemet CR or Sinemet with Comtan. Hopefully, this should be useful for overnight dosing as well.

In the mean time, what do folks do about this problem? Do you take a middle of the night dose? Do you do something else? Thanks in advance.

Folks here always have great ideas!

Howard