Parkinson's Disease Tulip


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Old 06-18-2012, 05:41 PM #1
Diego24
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Default Drug that Stops Progression of Parkinson's

http://www.disabled-world.com/disabi...rogression.php

Interesting article. What strikes me is that they are already testing it on humans. I wonder about the results. I have to admit though, that the med is not very practical. If it works, you need to take 32 tablets a day for neuroprotection. But if there are no extreme side-effects and it works ... why not ?

Anyway, the article is from 2011. And it states results would be published in a few months. We are now 1 year later. I didn't find any results. Also not on the website of the Michael J Fox foundation. It is really annoying to have no clue about such research that seems very promising in the beginning.
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Old 06-21-2012, 12:13 AM #2
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<Anyway, the article is from 2011. And it states results would be published in a few months. We are now 1 year later. I didn't find any results. Also not on the website of the Michael J Fox foundation. It is really annoying to have no clue about such research that seems very promising in the beginning.>

If it is the same study. it says here that they were looking for $$$ to fund study that will start in 2012.


http://www.drugdiscoverynews.com/ind...wsarticle=5196
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Old 06-21-2012, 03:53 AM #3
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Originally Posted by shetawk View Post

<Anyway, the article is from 2011. And it states results would be published in a few months. We are now 1 year later. I didn't find any results. Also not on the website of the Michael J Fox foundation. It is really annoying to have no clue about such research that seems very promising in the beginning.>

If it is the same study. it says here that they were looking for $$$ to fund study that will start in 2012.


http://www.drugdiscoverynews.com/ind...wsarticle=5196
Thanks for this. It is good to know it was tested on people and it appears to be safe. I hope they find the money soon to start the next clinical phases.
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Old 06-23-2012, 07:05 PM #4
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I found these articles that seems to be follow-up published May 2012.

http://blog.cncahealth.com/post/2012...s-Disease.aspx

http://www.examiner.com/article/ucla...sease-research

Also one mentioning MJFF for funding some of the research
http://www.eurekalert.org/pub_releas...-lsl020712.php

try google with time limit 2012, not sure there is as much progress as hoped but things are moving. I'm not sure this is as inclusive as you wanted but research/academia moves slower than we'd like.


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Thanks for this. It is good to know it was tested on people and it appears to be safe. I hope they find the money soon to start the next clinical phases.
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Old 06-23-2012, 07:14 PM #5
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Dogma, very interesting articles. Especially the last one. That's some ground breaking result I would say. With this technique you can get any protein passed the BBB. Amazing. I read about something similar yesterday somewhere on http://www.parkinsons.org.uk/.
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Old 06-23-2012, 07:21 PM #6
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http://www.pnas.org/content/early/20...56108.abstract

Is this the article? Interesting indeed.

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Dogma, very interesting articles. Especially the last one. That's some ground breaking result I would say. With this technique you can get any protein passed the BBB. Amazing. I read about something similar yesterday somewhere on http://www.parkinsons.org.uk/.
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Old 06-23-2012, 07:32 PM #7
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Default found another MJFF ref

http://healthcarenewsblog.com/parkin...foxs-activism/

Loads more with google drug that stops the progression of parkinson's and limit to 2012 or last year with advanced search.

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http://www.pnas.org/content/early/20...56108.abstract

Is this the article? Interesting indeed.
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Old 06-24-2012, 04:08 AM #8
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Quote:
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http://www.pnas.org/content/early/20...56108.abstract

Is this the article? Interesting indeed.
Dogma, this is not the article I mentioned. The article I mentioned is located somewhere on this site http://www.parkinsons.org.uk. It is some 2012 summer or spring or winter report. I would post the link but I just don't know where to find it anymore.

The article interviewed some researcher and asker her about what she thinks was the most promising yet found. She said that the alpha-synuclein path was one of the most remarkable things. But then she also started talking about something she was doing research on which was about a way to get proteins past the blood-brain barrier.

If I understood well the technique works by capturing the PD "curing" protein inside some closed sphere. The sphere hides the protein and is capable of entering the blood brain barrier. Once inside the brain, the protein is released and can start "curing" PD. This is really an important breakthough. Why ? For example, growth factors can't enter the blood brain barrier. With this technique it could enter very easily. So you wouldn't need these scary gene therapy technique in which they insert a needle in your brains and insert a virus. Also, researcher find many proteins and molecules that show they slow down or cure PD in animals but that are useless for people because the products don't cross the blood brain barrier. This is what happens with curcumin. So what researcher do next is try to modify these products so they do enter the brain barrier. But this is time consuming and slows down the cure. With this new technique you can get anything in the brain which speeds up the quest to find the cure. So I am very delighted about this research.

UPDATA: I found the article ... p. 14-15 of http://www.parkinsons.org.uk/pdf/Pro...winter2012.pdf This researcher will test exosomes to deliver meds to the brain. So it is still in the research phase and not yet proven to work well.
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Old 06-24-2012, 04:11 AM #9
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Originally Posted by d0gma View Post
http://healthcarenewsblog.com/parkin...foxs-activism/

Loads more with google drug that stops the progression of parkinson's and limit to 2012 or last year with advanced search.
Interesting article again. But my initial question was not about products that stops progression of PD. If you read the article I initially posted you will see that they found that some existing medecin (I think for leukemia) can change the expression of the DJ-1 gene. They tested this on mice and showed that it stopped/slowed down PD. They concluded they were going to test this on people and I was just wondering if they are already doing clinical trials on people because I didn't seem to find anything of this online.
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Old 06-24-2012, 07:56 AM #10
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you can always contact the author(s) of the paper or researcher via email,
i find that they usually respond.
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