[CarolynS]

Cogane phase II trials

"The profile of Cogane™ suggests that it will have benefit in both the motor and non-motor symptoms of Parkinson's disease. In addition its effect on restoring damaged neurones to a functioning state implies that it might result in a delay in the progression of disease in recently diagnosed patients.

Data from preclinical models also indicates that Cogane™ when administered in conjunction with L‑DOPA showed additional benefit over L‑DOPA alone. Other data suggests that Cogane™ reduces the side effects associated with L‑DOPA. If these effects of improved efficacy and reduced side effects of L‑DOPA by co-administration of Cogane™ are also observed in patients, this will have significant benefit in the management of patients with more severe disease.

CoganeTM is currently being evaluated in a 400 patient multi-national Phase II, randomised, double blind, placebo controlled, dose ranging study (CONFIDENT-PD). The study is comparing the safety, tolerability and efficacy of three doses of CoganeTM and placebo when administered for 28 weeks to untreated patients with early stage Parkinson's disease. The study will assess the efficacy of Cogane™ in the treatment of both motor and non‑motor symptoms of Parkinson's disease. Recruitment into the study is ongoing and expected to be completed in spring 2012, Our target remains to have results from the study available around the end of 2012."

[krugen68]

.....for the newly diagnosed and those not yet on meds, recruitment is ongoing until Q1 2012.

PM me if you want reassurance - I'm on it

Peter

[donlee]

Originally Posted by krugen68

.....for the newly diagnosed and those not yet on meds, recruitment is ongoing until Q1 2012.

PM me if you want reassurance - I'm on it

Peter

Peter,

I'm in week 23 of Cogane Trial. No changes yet. Must be on placebo or low dose.

Have you seen any changes?

Lee

[krugen68]

Originally Posted by donlee

Peter,

I'm in week 23 of Cogane Trial. No changes yet. Must be on placebo or low dose.

Have you seen any changes?

Lee

Hi Lee

I'm week 8 next week

Well I saw my GP (general doctor ) today for the first time in a while and she remarked that I seemed less rigid. In myself I feel better, and the other day I noticed I was swinging my left arm (not consistently as I tend to favour it ).
An abscess that has been persistently needing antibiotics every 3 or 4 months for the last 3 years, seems to have calmed down.
It's hard to make an objective assessment, as you are aware of yourself on a daily basis, rather than comparing how you felt a month or two back.
So far no bad side effects

How about when you compare yourself to 6 months ago ?

Peter

[donlee]

Originally Posted by krugen68

Hi Lee

I'm week 8 next week

Well I saw my GP (general doctor ) today for the first time in a while and she remarked that I seemed less rigid. In myself I feel better, and the other day I noticed I was swinging my left arm (not consistently as I tend to favour it ).
An abscess that has been persistently needing antibiotics every 3 or 4 months for the last 3 years, seems to have calmed down.
It's hard to make an objective assessment, as you are aware of yourself on a daily basis, rather than comparing how you felt a month or two back.
So far no bad side effects

How about when you compare yourself to 6 months ago ?

Peter

Hi Peter,

I really had not seen much change until a couple of weeks ago. Lip tremor has gotten a little worse. Recently started taking citalopram. My GP said citalopram could be causing this so I'm slowly getting off of it. Hopefully that will slow down the lip tremor. I was hoping for more from Cogane, but you never know. I guess I will finish the trial & go from there.

Keep me posted on your experience with Cogane. Hopefully it will work for you. They are already talking about Phase III from what my Dr said.

Lee

[krugen68]

Originally Posted by donlee

Hi Peter,

I really had not seen much change until a couple of weeks ago. Lip tremor has gotten a little worse. Recently started taking citalopram. My GP said citalopram could be causing this so I'm slowly getting off of it. Hopefully that will slow down the lip tremor. I was hoping for more from Cogane, but you never know. I guess I will finish the trial & go from there.

Keep me posted on your experience with Cogane. Hopefully it will work for you. They are already talking about Phase III from what my Dr said.

Lee

I'll be delighted if it just slows or stops the progression, any reversals of my PD symptoms would be a bonus

I just wish more new PDers would volunteer, so that the trial schedule and the clinical results aren't delayed. I'd love to see it moving quickly on to Phase III general trials for all.
Peter

[donlee]

Originally Posted by krugen68

I'll be delighted if it just slows or stops the progression, any reversals of my PD symptoms would be a bonus

I just wish more new PDers would volunteer, so that the trial schedule and the clinical results aren't delayed. I'd love to see it moving quickly on to Phase III general trials for all.
Peter

Same here. They are very picky about who they let in the trial. At Emory in Atlanta, they turned down several people for various reasons. They did increase the trial locations to get more people.
Hopefully they will get through & go on to Phase III.

Where are you from?

[krugen68]

Originally Posted by donlee

Same here. They are very picky about who they let in the trial. At Emory in Atlanta, they turned down several people for various reasons. They did increase the trial locations to get more people.
Hopefully they will get through & go on to Phase III.

Where are you from?

Sorry for the delay in replying, for some reason I cannot log onto here on my home PC

I'm from the UK, living to the south of London - my trial is through a major London teaching hospital, unfortunately I'm currently the only one on the trial there, and I found them and volunteered

[donlee]

Originally Posted by krugen68

Sorry for the delay in replying, for some reason I cannot log onto here on my home PC

I'm from the UK, living to the south of London - my trial is through a major London teaching hospital, unfortunately I'm currently the only one on the trial there, and I found them and volunteered

I live in Albany, Ga in the USA.

Is the Cogane working for you? I finish up next week. Ready to start on meds.

Does anyone have any sugestions for first time meds?

[GregD]

Originally Posted by krugen68

I just wish more new PDers would volunteer, so that the trial schedule and the clinical results aren't delayed. I'd love to see it moving quickly on to Phase III general trials for all.
Peter

The problem is, most new PDers are not aware that this trial even exist. From my 12 years of experience with PD and the doctors involved, new patients simply are not informed of clinical trials until it is too late. By that I mean they have already started other medications or they stumble across the information after the enrollment period has lapsed or the trial has been discontinued.