Paula & Vicky, Thanks for your encouragement. If I come across any more papers I can't access, I will let you know.
Vicky, Thanks for the Dutch report, but I think this is another version of the Prof Leenders paper that I mention in my summary. In fact I think we should call it Prof Leender's hypothesis, not mine. I did come to the same conclusion before I found his paper, but why hasn't this generated more interest? I don't however have his original article, and wonder how many PD people he examined, and did 100% of them show a defective BBB.

Ron

If you would like to e-mail the head of the research team to try to get your answers, Dr. Daniel Offen, the E-mail address is:

doffen@post.tau.ac.il

The article is downloadable from the University of Minnesota Medical Library
but will have to call my son who has a student ID and password to download it. Would you like it?

Vicky

Yes Vicky, thank you very much, I would very much like to see the complete paper.
Regarding your question about the spinal fluid analysis, I am sorry but I don't have the medical knowledge. However, if Dr Anne Frobert in France is
following this, maybe she could help us. As I understand it, we all have toxins of many types existing in our blood, including non-PD people, in whom the toxins circulate harmlessly in their blood.In our case, The BBB is leaky, defective, and allows thew toxins to get into the brain. Presumably blood could be analysed for both PD and non PD people,to identify what toxins are present, and no doubt there is a lot of information on this.
Best wishes
Ron

Hi Ron,

I have called my son who has a user name and password to allow me to download the research paper.

Have you seen this site? It links the Blood Brain Barrier with Everett's theory of the intestinal tract.

http://molecular.biosciences.wsu.edu...l/pall_mcs.htm

Best Regards,
Vicky

Ron-
Anne is on holiday until Monday but I am forwarding this to her so she will see it next week. It would be very interesting, indeed, to see some detailed information on the blood toxin load of the two groups. In fact, it would be great to have as much detailed data on our blood chemistry as possible - i.e. minerals, vitamins, lipids, etc. That is something we might get Tom Isaacs to fund through his group, at least for a limited number. Even ten of us could turn up something interesting, especially if we could determine beforehand what questions have not been asked. I, for one, would be appy to volunteer. Maybe Anne could help us on the tests to choose and we could put it in front of Tom.
-Rick

Vicky, Thanks again, look forward to receiving the full paper when you get it.
Rick, Yes, agree with your ideas. Presumably, both groups have similar toxins in their blood. The difference in our case is they leak through our defective BBB and cause cell death, or malfunction. Going to London today, but will do a search on blood toxins over the weekend.
Ron

PD is not the only neurological illness to have a defective Blood Brain Barrier.
It is also present in Multiple Sclerosis,
See
http://www.acceleratedcure.org:8080/node/2618
"One of the mysteries of MS is why the blood brain barrier (BBB) breaks down.....The BBB is a big flashing clue in MS that has not gotten the attention it most likely deserves."

So add the 300,000 MS sufferers to the 1 million+ PD sufferers, in the USA alone, and more targeted research on the role of the BBB is badly needed.

Ron