[soccertese]

http://www.pipelinereview.com/index....s-Disease.html

[pegleg]

This sure sounds like a potential answer to my dilemma. Diagnosed for 18 years, I have bad dyskinesia. And my nervousness (which I never hsad previously) and emotional lability just adds more dyskinesia.

It appears to be not only another delivery method for dopamine, but possibly a better drug to penetrate the blood brain barrier.

Quoting from release:
ND0612 is based on a proprietary sub-cutaneous levodopa/carbidopa drug formulation that bypasses the digestive tract. It continuously delivers levodopa to achieve straight-line and clinically-significant levodopa blood levels. It also delivers subcutaneous carbidopa to improve the bioavailability of oral levodopa. ND0612 is being developed for administration as an adjunct to oral levodopa via a subcutaneous delivery patch as a new treatment and intervention option in Parkinson's disease treatment. It should reduce off-time and improve the management of motor fluctuations even in patients under the best current standard of care with oral levodopa therapy.

Just a word of caution, however. This is only Phase I and look where the sponsoring company is located - (sigh)
Peg

[soccertese]

Originally Posted by pegleg

This sure sounds like a potential answer to my dilemma. Diagnosed for 18 years, I have bad dyskinesia. And my nervousness (which I never hsad previously) and emotional lability just adds more dyskinesia.

It appears to be not only another delivery method for dopamine, but possibly a better drug to penetrate the blood brain barrier.

Quoting from release:
ND0612 is based on a proprietary sub-cutaneous levodopa/carbidopa drug formulation that bypasses the digestive tract. It continuously delivers levodopa to achieve straight-line and clinically-significant levodopa blood levels. It also delivers subcutaneous carbidopa to improve the bioavailability of oral levodopa. ND0612 is being developed for administration as an adjunct to oral levodopa via a subcutaneous delivery patch as a new treatment and intervention option in Parkinson's disease treatment. It should reduce off-time and improve the management of motor fluctuations even in patients under the best current standard of care with oral levodopa therapy.

Just a word of caution, however. This is only Phase I and look where the sponsoring company is located - (sigh)
Peg

hopefully the "poor man's" duodopa.
if you look at their website, they don't even mention this patch, they do mention ND0611 which is cabidopa patch.
http://www.neuroderm.com/index.html

[Jim091866]

I am not going to get "up" about any meds or therapies for our disease. The @#$# FDA is a joke. We have people dying because of KNOWN contamination of a pharmacuetical company as well as a current therapy that is already in use in 40 countries, 40! and they still required complete protocols on it. Which this treatment has been on "fast track" since 2002! I've said it before and I'll say it again. If this were a medication for ED we'd have already seen it.

[soccertese]

Originally Posted by Jim091866

I am not going to get "up" about any meds or therapies for our disease. The @#$# FDA is a joke. We have people dying because of KNOWN contamination of a pharmacuetical company as well as a current therapy that is already in use in 40 countries, 40! and they still required complete protocols on it. Which this treatment has been on "fast track" since 2002! I've said it before and I'll say it again. If this were a medication for ED we'd have already seen it.

compounding pharmacy oversight was taken away from the FDA by congress, that is a totally seperate issue from drug approval. i understand your frustration but i don't think FDA incompetence is the primary issue. it could be the drug company.
taking your frustration out on posters here achieves what?
http://www.businessweek.com/articles...dow-pharmacies

[madamlash]

Originally Posted by soccertese

compounding pharmacy oversight was taken away from the FDA by congress, that is a totally seperate issue from drug approval. i understand your frustration but i don't think FDA incompetence is the primary issue. it could be the drug company.
taking your frustration out on posters here achieves what?
http://www.businessweek.com/articles...dow-pharmacies

I for one find it interesting that a company in Israel can come up with a very promising new treatment and start trials while literally under fire. Dodging bombs all the way! My respect goes out to them!