[reverett123]

If DK is a problem for you, look into this. It knocked mine completely out about two hours ago. Just now recovering ability to type so bear with me.

Herb known as lemon balm (melissa oficilnalis <sp>). Common. Any health food store. Calming. Long use as "nervine". But always made me dopey and had only sampled it over the years although my wife has quite a bit.

Had tested it last week at dose on label and was knocked on butt for two days! But noticed as I drifted away I noticed that a bout of DK that I was wrestling with abruptly disappeared! I rode out the next two days of dopeyness and returned to what passes for normal around here.

Had another bout of DK going this afternoon, driving wife mad. Thought it a good time to experiment again and opened a capsule. Took one-quarter of capsule. Label dose is three capsules. So I took one-twelfth of label.

DK disappeared in less than ten minutes! I got dopey but that turned around after an hour and is clearing up completely as I type. No sign of DK resuming even though I stuck to schedule and took a 10/100 about an hour ago.

So, for me at least, the herb stopped the DK at a dose that can still be reduced even lower and maybe even under the "dopey threshold."

Who wants to rid themselves of dyskinesia?
-Rick

Brand - Nature's Way
Melissa Leaves - 3 capsules per day equal to 1.47 grams as labeled. Last week I took two capsules. Today I took 1/4 capsule.

[wendy s]

I HOPE this works! I'm very afraid of dyskinesia, having seen it at its worst. I don't want it, and if a simple herb works, WOW!

[michael123]

[QUOTE=reverett123;943990]If DK is a problem for you, look into this. It knocked mine completely out about two hours ago.

Rick, interesting but not like you to describe in such broad terms. Please describe "dopey"? What is your plan for testing longer term? Do you intend to use this "on demand" or part of your daily regimen? I did a quick search on the product and came up with minimal
hits (so far) on PD. GOod luck.

[reverett123]

Welcome to the lab, Monitor1. Dopey refers to a state where one is aware of the world but too clumsy or impaired to do much about it. Then there is also the Walt Disney version, but I digress.... I don't have a plan at present but was surprised at the effect and, knowing that a lot of us deal with DK regularly thought that I would report it. I think that I will pick up a standardized tincture of some sort and try it as needed, but DK has not been a big problem for me. I hope someone else will follow up since I have a lot going on in a similar vein.

You are right about the lack of research. I consider that a plus since it marks it as an area that has not been looked at. If a search turns up a lot of negative results it is disheartening. But a simple lack of prior work is not. In fact, if the Grail is out there that is exactly how it would present. -Rick


[QUOTE=monitor1;944143]

Originally Posted by reverett123

If DK is a problem for you, look into this. It knocked mine completely out about two hours ago.

Rick, interesting but not like you to describe in such broad terms. Please describe "dopey"? What is your plan for testing longer term? Do you intend to use this "on demand" or part of your daily regimen? I did a quick search on the product and came up with minimal
hits (so far) on PD. GOod luck.

[reverett123]

Following up on yesterday- I slept for about two hours. Then I was up and functional until I went to bed about 9:00 with the first signs of DK returning. Slept well until about 2:00 AM when I had a bit of insomnia. My wife was up as well, however, so I hesitate to link it in.

-Rick

[reverett123]

For what it is worth-
1) Melissa inhibits cholinesterase, an enzyme.
Phytomedicine. 2012 Jun 15;19(8-9):836-9. doi: 10.1016/j.phymed.2012.03.010. Epub
2012 Apr 15.

Inhibition of cholinesterase by essential oil from food plant.

Chaiyana W, Okonogi S.

Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand.

Inhibition of cholinesterase has attracted much attention recently because of its
potential for the treatment of Alzheimer's disease. In this work, the
anticholinesterase activities of plant oils were investigated using Ellman's
colorimetric method. The results indicate that essential oils obtained from
Melissa officinalis leaf and Citrus aurantifolia leaf showed high
acetylcholinesterase and butyrylcholinesterase co-inhibitory activities. C.
aurantifolia leaf oil revealed in this study has an IC(50) value on
acetylcholinesterase and butyrylcholinesterase of 139 ± 35 and 42 ± 5 μg/ml,
respectively. GC/MS analysis revealed that the major constituents of C.
aurantifolia leaf oil are monoterpenoids including limonene, l-camphor,
citronellol, o-cymene and 1,8-cineole.

Copyright © 2012 Elsevier GmbH. All rights reserved.

PMID: 22510493 [PubMed - indexed for MEDLINE]

2) Apr 5, 2011 | By Leigh Wittman

Cholinesterase is an enzyme that aids in motor control. This enzyme is manufactured in the liver and red blood cells. Cholinesterase-inhibitors are sometimes used to manage Parkinson's disease symptoms. Although these medications tend to increase cognitive function, they also increase tremors and decrease motor control. Managing Parkinson's disease symptoms is a balancing act of managing cholinesterase levels. Consult your physician prior to taking any measures to increase your cholinesterase levels, as doing so may seriously impact your Parkinson's disease treatment.