[Lemonlime]

http://www.ncbi.nlm.nih.gov/pubmed/23339054
Mov Disord. 2013 Jan 21. doi: 10.1002/mds.25319. [Epub ahead of print]
Caffeine consumption and risk of dyskinesia in CALM-PD.
Parkinson Study Group.
Source
Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Abstract
BACKGROUND:
Adenosine A(2A) receptor antagonists reduce or prevent the development of dyskinesia in animal models of levodopa-induced dyskinesia.
METHODS:
We examined the association between self-reported intake of the A(2A) receptor antagonist caffeine and time to dyskinesia in the Comparison of the Agonist Pramipexole with Levodopa on Motor Complications of Parkinson's Disease (CALM-PD) and CALM Cohort extension studies, using a Cox proportional hazards model adjusting for age, baseline Parkinson's severity, site, and initial treatment with pramipexole or levodopa.
RESULTS:
For subjects who consumed >12 ounces of coffee/day, the adjusted hazard ratio for the development of dyskinesia was 0.61 (95% CI, 0.37-1.01) compared with subjects who consumed <4 ounces/day. For subjects who consumed between 4 and 12 ounces/day, the adjusted hazard ratio was 0.73 (95% CI, 0.46-1.15; test for trend, P = .05).
CONCLUSIONS:
These results support the possibility that caffeine may reduce the likelihood of developing dyskinesia © 2013 Movement Disorder Society.
Copyright © 2013 Movement Disorder Society.
PMID: 23339054 [PubMed - as supplied by publisher]