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01-31-2013, 02:36 PM | #1 | ||
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http://www.ncbi.nlm.nih.gov/pubmed/23339054
Mov Disord. 2013 Jan 21. doi: 10.1002/mds.25319. [Epub ahead of print] Caffeine consumption and risk of dyskinesia in CALM-PD. Parkinson Study Group. Source Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA. Abstract BACKGROUND: Adenosine A(2A) receptor antagonists reduce or prevent the development of dyskinesia in animal models of levodopa-induced dyskinesia. METHODS: We examined the association between self-reported intake of the A(2A) receptor antagonist caffeine and time to dyskinesia in the Comparison of the Agonist Pramipexole with Levodopa on Motor Complications of Parkinson's Disease (CALM-PD) and CALM Cohort extension studies, using a Cox proportional hazards model adjusting for age, baseline Parkinson's severity, site, and initial treatment with pramipexole or levodopa. RESULTS: For subjects who consumed >12 ounces of coffee/day, the adjusted hazard ratio for the development of dyskinesia was 0.61 (95% CI, 0.37-1.01) compared with subjects who consumed <4 ounces/day. For subjects who consumed between 4 and 12 ounces/day, the adjusted hazard ratio was 0.73 (95% CI, 0.46-1.15; test for trend, P = .05). CONCLUSIONS: These results support the possibility that caffeine may reduce the likelihood of developing dyskinesia © 2013 Movement Disorder Society. Copyright © 2013 Movement Disorder Society. PMID: 23339054 [PubMed - as supplied by publisher] |
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"Thanks for this!" says: | soccertese (01-31-2013) |
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