Well, for me those were unbearable side effects that went away when i stopped taking sinemet and have not returned. My Dr insisted that that would not help but make it worse....ha!
Most dont like to hear that for some reason but there it is.


Peace BP

BP: I tend to agree with you on Sinemet side efffects & also that some doctors & even some patients don't want to hear my experience if it doesn't jibe with theirs. Sometimes people generalize and assume all Parkies are alike in symptoms & treatment responses, but it just ain't so. Sinemet doesn't do much if anything for my main symptom, a really bad tremor, but at this stage, 6 years after diagnosis, it does seem to help improve slowness, sleep, and at least one specific horrendous upper back pain. Unfortunately, it also gave me some bad side effects: weak legs and right foot/toes & leg curling upward & inward plus muscle cramping. I keep the dosage low, but seems nothing's ever perfect in Parkie land!

Thanks for your interesting reply. Please tell me more about your experience, and also have you found anything (meds or other) that works well for you? See more about my similar experience, posted today under the current thread about stopping Sinemet.

Thanks to all about the B-12 ideas, but I've already been doing that angle due to some info I found out about on 23andMe.com. Hasn't improved leg weakness, etc.