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05-24-2013, 07:32 AM | #1 | |||
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Homocysteine is a link between Parkinson’s disease and depression
By Geoff Michaels, May 23rd, 2013 http://www.newsfix.ca/2013/05/23/hom...nd-depression/ A study finds out that high levels of homocysteine make a patient with Parkinson’s disease more likely to suffer from depression. We already know that elevated levels of the amino acid homocysteine are a risk factor for dementia and Alzheimer’s disease. And high levels are also linked to impaired cognition, even if people don’t actually have dementia. Those with Parkinson’s disease are at risk of elevated homocysteine because of the drugs they take.
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In the last analysis, we see only what we are ready to see, what we have been taught to see. We eliminate and ignore everything that is not a part of our prejudices. ~ Jean-Martin Charcot The future is already here — it's just not very evenly distributed. William Gibson |
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"Thanks for this!" says: | anon72219 (05-24-2013) |
05-24-2013, 09:39 AM | #2 | ||
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Hi Olsen, I believe that high levels of homocysteine are also found in B12 deficiency. Possibly related?
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05-24-2013, 08:10 PM | #3 | ||
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I have always believed homocysteine was a marker of inflammation in the body...so you want that number low, in the single digits.
Anytime you get a blood test, I'd get the homocysteine checked. You have to ask for it, it's not included in the standard CBC. Then keep track of your levels, and notice your lifestyle changes, if any. Try to live how you lived when the level was at its lowest. Homocysteine is very commonly associated with heart attack risk....another good reason to know what your level is and keep it low |
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05-24-2013, 08:34 PM | #4 | |||
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Hi Lindylanka, Yes, high homocysteine is associated with deficient B 12 levels. Also, high homocysteine levels occur with other "methylation pathway" factors including folic acid, and Vitamin B 6. Vitamin B12 functions as a co factor with the breakdown of folic acid (5-methyl tetrahydrofolate) to react with homocysteine to make methionine. Without this result (making methionine from homocysteine), high levels of homocysteine results.
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In the last analysis, we see only what we are ready to see, what we have been taught to see. We eliminate and ignore everything that is not a part of our prejudices. ~ Jean-Martin Charcot The future is already here — it's just not very evenly distributed. William Gibson |
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05-24-2013, 10:12 PM | #5 | |||
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Which PD med is associated with the higher levels? The article doesn't specifically say.
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Carey “Cautious, careful people, always casting about to preserve their reputation and social standing, never can bring about a reform. Those who are really in earnest must be willing to be anything or nothing in the world’s estimation, and publicly and privately, in season and out, avow their sympathy with despised and persecuted ideas and their advocates, and bear the consequences.” — Susan B. Anthony |
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05-25-2013, 02:44 AM | #6 | |||
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Hi Carey, Levodopa therapy is associated with high homocysteine levels. The COMT pathway is involved in the production of homocysteine from the conversion of levodopa. COMT inhibitors decrease this reaction. The increase in homocysteine levels does not occur with dopamine agonists.
(from my notes--do not have the reference) Plasma total homocysteine depends on folic acid, B6 , B2 and B 12 which work together to support methylation from total homocysteine to methionine. However methylation of levodopa and dopamine by COMT interferes with this process by consuming methyl groups in the transmethylation reactions thereby increasing S-adenosylhomocyteine (SAH) concentrations in tissues which is rapidly converted to homocysteine, as well as significant decreases of SAMe. Animal studies show levodopa induced hyperhomocysteinemia is consequence of significant O-methylation and that the COMT inhibitors can prevent such elevation of Hcy concentrations by reducing the O-methylation of levodopa. Findings indicate levodopa induced hyperhomocysteinemia can be caused by competition at site of methylation, rather than by a defieiency of folate or other B vitamins (I have read levodopa and B 6 should not be taken together, but that B6 is not contraindicated when taking levodopa. There is evidence one should not take too much B6 )
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In the last analysis, we see only what we are ready to see, what we have been taught to see. We eliminate and ignore everything that is not a part of our prejudices. ~ Jean-Martin Charcot The future is already here — it's just not very evenly distributed. William Gibson Last edited by olsen; 05-25-2013 at 03:04 AM. |
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"Thanks for this!" says: | indigogo (05-25-2013), lindylanka (05-25-2013) |
05-25-2013, 10:59 AM | #7 | |||
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Could you assist in the question of taking supplemental B6 and Levodopa? I have read one should not take these together--though with further reading, think the information is one should not take them together, but one can take B6 1 to 2 hrs before or after levodopa. Any help? thanks, madelyn
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In the last analysis, we see only what we are ready to see, what we have been taught to see. We eliminate and ignore everything that is not a part of our prejudices. ~ Jean-Martin Charcot The future is already here — it's just not very evenly distributed. William Gibson |
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05-31-2013, 07:13 AM | #8 | ||
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B6 determines haw quickly is Levodopa absorbed in a body.But this is not a problem if you take it with carbidopa/ Sinamet. Carbidopa prevents this .
Zlatica PS.IF you take combination Carbidopa-Levodopa/ Sinamet it is OK to take B6. |
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"Thanks for this!" says: | olsen (05-31-2013) |
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