...“Two years ago, if you talked about the blood-brain barrier, you’d hear, ‘Eh, okay, another failure.’ People criticized all sorts of approaches, showing no interest,” says Jean-Paul Castaigne, CEO of AngioChem, a Montreal-based biotech company developing treatments for brain diseases. Today, however, “we are seeing a major shift,” he says. “As often happens, one starts and the others follow.”

Genentech’s early achievements breaching the BBB have opened the floodgates. These days crossing the barrier is in vogue, with numerous companies and academics devising diverse, creative, and sometimes downright wacky ways to pry open a window into the brain. In doing so, they hope to deliver drugs that will treat Alzheimer’s disease, multiple sclerosis, Parkinson’s disease, and many more brain illnesses that are currently intractable..."

http://www.the-scientist.com//?artic...ing-the-Brain/