[olsen]

By Linda Herman

http://www.pdblogger.com/gdnf-saga-2...sonal-account/

Past and present history of GDNF trials

[zanpar321]

Originally Posted by olsen

By Linda Herman

http://www.pdblogger.com/gdnf-saga-2...sonal-account/

Past and present history of GDNF trials

Thanks for posting the GDNF history.

As some of you know GDNF is increased by exercise!

http://d-scholarship.pitt.edu/9875/

http://www.academia.cat/files/425-18...8-23Maig11.pdf

[Tupelo3]

Originally Posted by olsen

By Linda Herman

http://www.pdblogger.com/gdnf-saga-2...sonal-account/

Past and present history of GDNF trials

Thanks Madelyn, that was a great summary of the GDNF saga.

[GerryW]

Good article. Thanks for posting it.

Too bad I am not far gone enough to qualify for the trial. UCSF is only 30 miles away.

In the meantime, here's a relevant repost from the late, great Reverett123

http://neurotalk.psychcentral.com/thread169317.html

I might try a little kudzu when my current experiment with cinnamon is over.

[zanpar321]

Originally Posted by GerryW

Good article. Thanks for posting it.

Too bad I am not far gone enough to qualify for the trial. UCSF is only 30 miles away.

In the meantime, here's a relevant repost from the late, great Reverett123

http://neurotalk.psychcentral.com/thread169317.html

I might try a little kudzu when my current experiment with cinnamon is over.

Here's a great GDNF History and Primer!

Moreover, given its involvement in synaptic plasticity and synaptogenesis, GDNF also plays a role in learning and memory. One may therefore speculate that increasing the endogenous GDNF expression would also contribute to fight the cognitive decline observed in PD patients. Additionally, it would be interesting to examine the effect of caloric restriction, physical exercise, enriched environment, herbal extracts or acupuncture, which increase GDNF expression in the nigrostriatal system and are neuroprotective in PD.


http://cdn.intechopen.com/pdfs-wm/22885.pdf

[olsen]

“We found that by culturing aging astrocytes and those harboring the ALS mutation with a neuron-protective protein called GDNF, we could increase motor neuron survival. We already knew that GDNF was protective directly on motor neurons, but we believe this is the first time that the delivery of GDNF has been shown to have a direct beneficial effect on astrocytes, perhaps resetting their aging clock, which ultimately benefits neurons,” Svendsen said.

http://www.psypost.org/2014/11/lou-g...-survive-29184

[Betsy859]

Originally Posted by GerryW

Good article. Thanks for posting it.

Too bad I am not far gone enough to qualify for the trial. UCSF is only 30 miles away.

In the meantime, here's a relevant repost from the late, great

I might try a little kudzu when my current experiment with cinnamon is over.

Hi Gerry,

Do you have any idea how much cinnamon we should be taking? What I take daily is a 500mg capsule made by the supplement company "Stop Aging Now," and Ceylon cinnnamon from Penzey Spices heavily put in tea and on vegetables and meat before it's cooked. I guess I've been doing this about a month now. Results have been neutral no better no worse. How about you? Any idea where kudzu comes in edible form?
Thank you and all the best.
Betsy

[GerryW]

Originally Posted by Betsy859

Hi Gerry,

Do you have any idea how much cinnamon we should be taking? What I take daily is a 500mg capsule made by the supplement company "Stop Aging Now," and Ceylon cinnnamon from Penzey Spices heavily put in tea and on vegetables and meat before it's cooked. I guess I've been doing this about a month now. Results have been neutral no better no worse. How about you? Any idea where kudzu comes in edible form?
Thank you and all the best.
Betsy

Hi Betsy

I have no idea how much cinnamon to take but I take 1200 mg of Ceylon cinnamon by NOW foods per day as a single dose. I've done this for a couple of months now but without any discernible effect. It could be slowing progression but that is impossible to measure so I was looking for any kind of symptom change.

Kudzu capsules are available from Nature's Way, a brand common in health food stores.

Gerry

[zanpar321]

Originally Posted by GerryW

Hi Betsy

I have no idea how much cinnamon to take but I take 1200 mg of Ceylon cinnamon by NOW foods per day as a single dose. I've done this for a couple of months now but without any discernible effect. It could be slowing progression but that is impossible to measure so I was looking for any kind of symptom change.

Kudzu capsules are available from Nature's Way, a brand common in health food stores.

Gerry

I've been taking Kudzu the past week and haven't seen any improvement but will try it for a month or 2. Puerarin (which is derived from Kudzo) appears to increase GDNF and glutathione. I'm not sure that happens in humans though.

http://www.ncbi.nlm.nih.gov/pubmed/23512787

Puerarin protects dopaminergic neurons in Parkinson's disease models

[Betsy859]

Originally Posted by GerryW

Hi Betsy

I have no idea how much cinnamon to take but I take 1200 mg of Ceylon cinnamon by NOW foods per day as a single dose. I've done this for a couple of months now but without any discernible effect. It could be slowing progression but that is impossible to measure so I was looking for any kind of symptom change.

Kudzu capsules are available from Nature's Way, a brand common in health food stores.

Gerry

Thank you Gerry for your input. I agree it's impossible to measure any slowing of PD progression just hopefully staying stable is a victory. I'll try increasing my cinnamon dosage to 1000mg plus add it to my food and see if anything changes. It's supposed to be good for you anyway according to the supplement company, of course, what else are they going to say?? I'll let you know if anything changes. Not sure I'm going to add kudzu at this time. I don't think I could stand to take one more capsule of anything at this point.
Good luck to us and everyone else!
Betsy