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03-04-2015, 07:33 AM | #1 | ||
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Junior Member
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It seems you have to saturate your system with thiamine in order to get it to your brain. I wonder if anyone has tried sulbutiamine. It is an OTC synthetic thiamine analog that easily crosses the blood-brain-barrier.
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"Thanks for this!" says: | sim00 (03-10-2015) |
03-04-2015, 08:02 AM | #2 | ||
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Quote:
http://www.longecity.org/forum/topic...verse-affects/ |
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"Thanks for this!" says: | sim00 (03-10-2015) |
03-04-2015, 08:12 AM | #3 | ||
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http://www.lifeosome.com/?page_id=6389 and here's a lipsomal B-1 with 137mg http://www.livonlabs.com/cgi-bin/sta...e-blocker.html Last edited by zanpar321; 03-04-2015 at 08:37 AM. |
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03-04-2015, 10:51 AM | #4 | ||
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[QUOTE=Deangreen;1127299]It seems you have to saturate your system with thiamine in order to get it to your brain. I wonder if anyone has tried sulbutiamine. It is an OTC synthetic thiamine analog that easily crosses the blood-brain-barrier.[/QUOTE
This doesn't make sense to me. If something doesn't normally get into the brain (ie, it does not cross the BBB, is that what you are saying?) then how does flooding the body with it resolve that problem? I think every person on the planet would have thiamine deficiency if you had to flood the body with thiamine to get it into the brain. Where did you read this? Don't mean to be combative, just curious. Everything I've read is to the contrary, actually, that the body can only absorb so much thiamine and if you take in more than that, you'll just pee it out. |
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"Thanks for this!" says: | sim00 (03-10-2015) |
03-04-2015, 11:57 AM | #5 | ||
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[QUOTE=lurkingforacure;1127341]
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Regarding Thiamine, rather than saturating our body with Thiamine, it makes more sense to get IM thiamine injections or even take liposomol thiamine which allows more to get absorbed. Liposomol allows it to be protected in lecithin spheres until it gets further down the gut and thus more gets absorbed. What seems important is to get it into the brain before the body breaks it down and it gets removed. |
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"Thanks for this!" says: | sim00 (03-10-2015) |
03-04-2015, 02:29 PM | #6 | ||
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[QUOTE=lurkingforacure;1127341]
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03-10-2015, 06:11 AM | #7 | |||
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__________________
Sim00 Born in 1969, diagnosed PD in 2007, first symptoms 2004. DBS in July 2016. |
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03-10-2015, 07:42 AM | #8 | ||
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Magnate
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[QUOTE=zanpar321;1127355]
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Carrier-mediated transport enables molecules with low lipid solubility to traverse the blood-brain barrier. Glucose from blood enters the brain by a transport protein. Glucose is the primary energy substrate of the brain. Glucose transport protein (GLUT-1) is highly enriched in brain capillary endothelial cells. These transporters carry glucose molecules through the blood brain barrier. Although rare, patients with Glut-1 deficiency (caused by genetic mutations) can have severe learning difficulties. Low glucose sugar levels in the cerebrospinal, but not in the blood, will identify the condition. The essential amino acids cannot be synthesized by the brain and, therefore, must be supplied from protein breakdown and diet. Phenylalanine, leucine, tyrosine, isoleucine, valine, tryptophan, methionine and histidine, which are essential amino acids, and also the precursor of dopamine, L-DOPA, enter the brain as rapidly as glucose. These amino acids are transported into the brain by the leucine-preferring or the L-type transport proteins. These compounds compete with each other for entry into the brain. Therefore, an elevation of plasma level of one will inhibit uptake of the others. This competition may be important for certain metabolic diseases such as phenylketonuria (PKU), where high levels of phenylalanine in plasma reduce brain uptake of other essential amino acids. Small neutral amino acids, such as alanine, glycine, proline and GABA (gamma-aminobutyric acid), are markedly restricted in their entry into the brain. These amino acids are non-essential amino acids and are transported by alanine-preferring or A-type transport protein. The A-type transport protein is not present on the luminal surface of the blood brain barrier. In contrast, these small neutral amino acids appear to be transported out of the brain across the blood-brain-barrier. http://neuroscience.uth.tmc.edu/s4/chapter11.html |
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03-24-2015, 03:02 PM | #9 | ||
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There's another form of thiamine from garlic. It's called allithiamine and it does penetrate the blood brain barrier as well.
Does anyone have anything new to say about sulbutiamine? Is it working for you? While I was researching this I found a comment that stated that the manufacture of sulbutiamine is suspect, though it was seemingly a knowledgeable source, it was an offhand statement so I'm not sure if it has any validity. I'm gonna try this allithiamine (swallow it fast cause it's very garlicky and you'll lose all your friends) and see how it goes. I am having great success with B2 tabs BTW. 100 mg x2 a day. Also some family members are finding big changes with it too. Maybe my family is predisposed to poor B2 absorption .. I dunno, but it's been a big improvement for me so far. |
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03-24-2015, 05:04 PM | #10 | ||
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Hi Breezy Racer -- Great you are having a good experience w/B2 tabs. Would you be able to share a bit more info about what kind of changes you are experiencing?
Quote:
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Looking for different options for my mom, born 1946 and dX with PD in 2010. |
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