Originally Posted by ashleyk

My wife was on Zonisamide for about 3 years. Her MDS discontinued it a few months ago because we thought it wasn't doing much good. The MDS put her on Rytary which seems to prolong her on times but she still needs about 3 fast relief Sinemet each day. She is well over the equivalent of 1200mg CLD.
She was on low dose naltrexone, LDN, for about 6 years (started 11 years ago) and it did not seem to help. Her PD has advanced to where she has serious hallucinations and delusions. She just started Nuplazid for PD psychosis. She is not a candidate for DBS because of psychosis.

Originally Posted by ashleyk

My wife has been on Nuplazid for about 4 weeks now. She still has the hallucinations and delusions but she may be more calm and reasonable. The drug is Very Expensive, I pay $40 copay for 30 day Rx. It take about 6 weeks to show its effectiveness but nothing dramatic so far.
My wife is/has been on Seroquel, Geodone, Mirtazapine and has had 16! ECT treatments (this summer). Nothing has helped much with the psychosis (many ER visits). If the Nuplazid does not work I think they'll try Clozapine and if that doesn't work it's a nursing home?