Go Back   NeuroTalk Support Groups > >

Parkinson's Disease Tulip

Some more CYP3A4 inhibitors

Reply
 
Thread Tools Display Modes
Old 07-04-2019, 09:23 PM   #1
johnt
Senior Member
 
Join Date: Apr 2009
Location: Stafford, UK
Posts: 1,014
Default Some more CYP3A4 inhibitors

People following the grapefruit thread started by Albert are familiar with the argument that the enzyme CYP3A4 helps metabolize levodopa. Inhibiting it slows the metabolism and leads to more levodopa in the body. Unfortunately, CYP3A4 has the same effect on many other drugs; inhibiting CYP3A4 in effect magnifyies their dose, thus possibly leading to dangerous over-dose situations.

Evidence-Based Medicine have written a paper [1] which lists CYP3A4 inhibitors. Those shown below are some of those of moderate strength (defined as between a 2 to a 5-fold increase in AUC and a decrease in clearance of between 50 and 80%).

I thought it would be useful to look at the archives of this forum to see if anyone had reported benefits involving these substances:

- Miconazole, no mention
- Grapefruit juice [4]
- Cat's claw, not specific
- Echinacea, not specific
- Wild cherry [3, for winter cherry]
- Chamomile, not specific
- Licorice [2]

Reference

[1] "Common Medications Classified as Weak, Moderate and Strong Inhibitors of CYP3A4"
Anthony Busti
Evidence-Based Medicine, Consult, 2015
What are some common medications classified as weak, moderate and strong inhibitors of CYP3A4?

[2] Can licorice help those with PD?

[3] Post 10, Waiting on Levodopa

[4] How to double your on time!!

John
__________________
Born 1955. Diagnosed PD 2005.
Meds 2010-Nov 2016: Stalevo(75 mg) x 4, ropinirole xl 16 mg, rasagiline 1 mg
Current meds: Stalevo(75 mg) x 5, ropinirole xl 8 mg, rasagiline 1 mg
johnt is offline   Reply With Quote
"Thanks for this!" says:
eds195 (07-04-2019), jeffreyn (07-05-2019), wriga (07-06-2019)
Old 07-06-2019, 03:51 PM   #2
wriga
Junior Member
 
Join Date: Mar 2019
Location: Grenoble, France
Posts: 12
Default

Reference 1 in John's post is very useful since it gives a simple table of commonly prescribed drugs which are also CYP3A4 inhibitors. It would be useful to know if any PwP , already taking levodopa in some form ir other, had noticed any effects, positive or negative, when taking these drugs prescribed for another condition.
It would also be useful to know if they were warned about possible drug-drug interactions by their Dr or pharmacist.
wriga is offline   Reply With Quote
Reply

Tags
cyp3a4, effect, inhibitors, medicine, specific

Thread Tools
Display Modes

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off


Similar Threads
Thread Thread Starter Forum Replies Last Post
Alternative cholinesterase inhibitors Hopful Myasthenia Gravis 3 08-17-2018 09:39 AM
Anyone have experience with MAO inhibitors? BreezyRacer Parkinson's Disease 11 07-21-2015 10:06 AM
natural mao-b inhibitors soccertese Parkinson's Disease 12 07-21-2013 11:20 AM
Requip and MAO Inhibitors bryn Parkinson's Disease 6 01-06-2009 01:06 AM


All times are GMT -5. The time now is 01:22 PM.
Brought to you by the fine folks who publish mental health and psychology information at Psych Central Mental Health Forums

The material on this site is for informational purposes only, and is not a substitute for medical advice, diagnosis or treatment
provided by a qualified health care provider. Always consult your doctor before trying anything you read here.


Powered by vBulletin • Copyright ©2000 - 2019, Jelsoft Enterprises Ltd.
Search Engine Optimisation provided by DragonByte SEO v2.0.31 (Lite) - vBulletin Mods & Addons Copyright © 2019 DragonByte Technologies Ltd.

vBulletin Optimisation provided by vB Optimise v2.7.1 (Lite) - vBulletin Mods & Addons Copyright © 2019 DragonByte Technologies Ltd.

All posts copyright their original authors Community Guidelines Terms of Use Privacy Policy