Parkinson's Disease Tulip

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Old 02-17-2020, 01:02 PM #1
ashleyk ashleyk is offline
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ashleyk ashleyk is offline
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Join Date: Oct 2006
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Default Cough Syrup PD

I remember this from years ago. Time to look again?



New secret weapon against Parkinson’s might actually be… COUGH SYRUP? — RT World News
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Old 02-18-2020, 12:24 PM #2
ashleyk ashleyk is offline
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ashleyk ashleyk is offline
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Default repurposing Ambroxol for the treatment of PD

Can anyone add to this? Where is evidence from the past?



The Ambroxol Trial - The facts | The Cure Parkinson's Trust



Ambroxol as a novel disease-modifying treatment for Parkinson’s disease dementia: protocol for a single-centre, randomized, double-blind, placebo-controlled trial | BMC Neurology | Full Text



Cognitive decline and its implications to the life of individuals with PDD represent a significant burden to patients, caregivers, and the health care system. Current pharmacological therapies are helpful for cognitive symptoms in PDD but are unable to modify the course of disease progression, making treatment for cognition in PDD a major unmet need. Increasing levels of the GCase enzyme has been proposed as a potential therapy for slowing neurodegeneration in Parkinsonís disease, and consequently PDD. There is increasing evidence in cell culture and animal models of PD that Ambroxol can raise levels of GCase. Strikingly, increased levels of GCase were accompanied by decreased levels of α-synuclein aggregation in brain areas of mice treated with Ambroxol. The present trial is the first to test Ambroxol in human subjects with PDD. The effects of Ambroxol will be measured using standardized cognitive, functional, behavioural, biochemical, as well as brain imaging outcomes. Results from this clinical trial may have a large impact in the research of disease-modifying therapies for PDD and other synucleinopathies including Parkinsonís disease and Lewy Body dementia. Importantly, Ambroxol is a drug already commercially available in most of the world and has an excellent safety record. Thus, repurposing Ambroxol for the treatment of PDD may expedite a potential disease-modifying treatment and circumvent a lengthy drug development process.
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Old 02-19-2020, 08:32 PM #3
jeffreyn jeffreyn is offline
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Default "Ambroxol for PD" background info

There is quite a lot of background information in this recent SoPD blog post from Simon Stott:
The Ambroxol Results | The Science of Parkinson's
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