Hi,
I haven't posted in awhile. I too recently lost my wife to Parkinson's this past Nov. She was dx about 21 years ago at age 52. Her last ten years were increasingly hard with dementia a main issue. When she was first dx, I thought I could fix her and got on the internet. I came across LDN, low dose naltrexone, and she took it for seven years until she said it wasn't working and stopped. I don't know if it helped. If PD is a neuro inflammatory disease as they now claim, it makes sense to take a anti-inflammatory supplement. My past research on this came up with Curcumin. It's not the cure that we have hoped for but, maybe, it will slow progression.
I first joined the old BrainTalk until moving to this site. I guess I made a lot of posts. I can't see much progress in real world PD treatments since Levo-dopa first came into use. As far as I'm concerned, it's the only treatment that helps. I am amazed that an almost cure has not been found yet. To all of you in the PD fight, I know how hard it can be. I wish you the best,
John Maccini

I am so sorry for your loss. I also am surprised we have nothing better than levodopa after all of this time and money. It is very discouraging, but there are some things that I think provide those of us in the PD community with hope:

1. I am following the autologous stem cell researchers and hope that this can be a treatment for PWP soon.

2. I was optimistic to read about Inflazome's acquisition by Roche for almost half a billion dollars in late 2020, but it just disappeared off the radar once the acquisition was made. Inflazome's research sounded quite promising, dealing with inflammation, and two of their drug candidates had already completed Phase 1 safety. You can read more about this here:

https://cen.acs.org/business/mergers...million/98/i37

Wishing you all a safe and healthy 2023