Below is a 3 month study that says 300 mg of Coenzyme Q10 is enough to provides the same plasma levels as 1200 mg. Note the study was for 3 months and it determined there was no apparent symptom relief. Also nothing was said about neuroprotection for Q10.
So, save your money and only take 300 mg of Q10?
ashley

http://www.ncbi.nlm.nih.gov/sites/en..._uids=17502459
CONCLUSIONS: Nanoparticular CoQ(10) at a dosage of 300 mg/d is safe and well tolerated and leads to plasma levels similar to 1200 mg/d of standard formulations. Add-on CoQ(10) does not display symptomatic effects in midstage Parkinson disease.

of PD symptomatic relief for any amount of CoQ10. The only claims that I am aware of are for some slowing of progression of symptoms in recently diagnosed patients in Shults' small study in 2002. The effect was greatest in patients recieving 1200 mg/day. What was observed was that those taking 1200 mg per day of CoQ10 were able to delay the start of sinemet or agonist use for symptomatic relief longer than those who took 300 or 600 mg/day or placebo.

The study used a nanoparticle formulation. If you can find that, then it seems 300 mg a day is enough.

Preparation and Characterization of Novel Coenzyme Q 10 Nanoparticles Engineered from Microemulsion … -

http://www.aapspharmscitech.org/arti...2/pt040332.pdf

There's a Japanese formulation that I think is available as Q-sorb, but I don't know if it's the same. I purchased some by Nature's Bounty at CVS, buy one, get one free.

Darn....

Journal of Medicinal Food
A New Coenzyme Q10 Tablet-Grade Formulation (all-Q®) Is Bioequivalent to Q-Gel® and Both Have Better Bioavailability Properties than Q-SorB®
To cite this paper:
U. Ullmann, J. Metzner, C. Schulz, J. Perkins, B. Leuenberger. Journal of Medicinal Food. 2005, 8(3): 397-399. doi:10.1089/jmf.2005.8.397.


U. Ullmann
R&D Human Nutrition & Health, DSM Nutritional Products Ltd., Kaiseraugst, Switzerland.
J. Metzner
GALMED Institute for Galenic & Medicine Research, Halle/Saale.
C. Schulz
BIOTESYS GmbH, Esslingen, Germany.
J. Perkins
R&D Human Nutrition & Health, DSM Nutritional Products Ltd., Kaiseraugst, Switzerland.
B. Leuenberger
R&D Human Nutrition & Health, DSM Nutritional Products Ltd., Kaiseraugst, Switzerland.

Commercial Coenzyme Q10 (CoQ10, ubiquinone) formulations are often of poor intestinal absorption. We investigated the bioavailability of DSM Nutritional Products Ltd. (Kaiseraugst, Switzerland) CoQ10 10% TG/P (all-Q®), a new tablet-grade formulation, with CoQ10 Q-Gel® Softsules® based on the Bio-Solv® technology (Tishcon Corp., Salisbury, MD; marketed by Epic4Health™, Smithtown, NY) and Q-SorB® (Nature's Bounty™, Bohemia, NY). Twelve healthy male subjects participated in a randomized, three-period crossover bioequivalence study. Plasma CoQ10 was determined from pre-dose until +36 hours. To compare bioavailability, corrected maximum concentration (C max) and area under the curve from 0 to +14 hours [AUC(0-14 h)] were assessed and tested for bioequivalence. The bioequivalence ranges of 0.8–1.25 hour × µg/mL for AUC(0-14 h) and 0.75–1.33 µg/mL for C max were applied. In summary, the kinetic profiles of all CoQ10 preparations revealed a one-peak plasma concentration–time course. Highest C max values were seen after Q-Gel application, whereas time to C max was nearly identical across all treatments. The AUC(0-14 h) values were highest for Q-Gel, narrowly followed by all-Q. The tests for bioequivalence showed a bioequivalence between Q-Gel and all-Q, and both preparations were found to have better bioavailability properties than Q-SorB. Although all-Q and Q-Gel have equivalent bioavailability properties, all-Q can be directly used in tablets, while this is not the case for Q-Gel or other similar forms.

http://www.qgel.com/

http://www.swansonvitamins.com/webap...urlID=31363043

ALL-Q™ (Coenzyme Q10) - for foods, beverages and tablets


DSM Nutritional Products (www.dsmnutritionalproducts.com), the former Vitamins and Fine Chemicals Division of Roche, is a globally leading supplier of high quality and performance nutrients to food, functional food and supplement manufacturers. A major skill of DSM Nutritional Products is its experience in formulating nutrients such as vitamins or carotenoids in order to offer easily applicable product forms to food and supplement manufacturers.

The new DSM brand ALL-Q™ (Coenzyme Q10) is the company's response to the growing demand of manufacturers for easily applicable and bioavailable forms of Coenzyme Q10. Traditionally, Coenzyme Q10 was marketed in its crystalline form. The crystals were suspended in oil and then encapsulated in soft gelatine capsules. Tablet grade forms of Coenzyme Q10 were not available. The crystals of Coenzyme Q10 are fat soluble and thus had little or no application in food fortification. DSM Nutritional Products has recognised that providing a water soluble form of will open up new markets and create new products opportunities also for its customers in the food and beverage industries. The new ALL-Q™ (Coenzyme Q10) range includes two products with enhanced bioavailability and physical properties that facilitate the use in various kinds of foods, beverages and supplements.

ALL-Q™ (Coenzyme Q10) 10% TG/P is a dry powder produced from poultry gelatine using patented DSM technology. It enables supplement developers to address the growing demand for Coenzyme Q10 by expanding the delivery options. It facilitates the coenzyme's use in supplements such as multivitamin and single-entity tablets, antioxidant tablets and two-piece hard shell gelatine capsules. The excellent product performance includes extremely low extrusion losses in tabletting and stability.

ALL-Q™ (Coenzyme Q10) 10% CWS/S is a starch based food grade powder using DSM's experience with other fat soluble nutrients such as carotenoids. The product is cold water soluble and stable in beverages. Being neutral in taste and containing only vegetarian ingredients ALL-Q™ (Coenzyme Q10) 10% CWS/S enables product developers to complete their range of beverages and effervescent tablets with products responding on actual consumer demand.

Coenzyme Q10 (also called Ubiquinone or CoQ10) is a natural, vitamin-like compound found in cell mitochondria of plants and animals. Approximately 95% of the body's energy is activated by CoQ10 and it is an essential cofactor in the generation of energy (ATP). CoQ10, although found in many foods, studies show that dietary intake of CoQ10 is low. It is found in most body tissues, but levels are declining with age. Low CoQ10 levels have been observed in a number of diseases and thus an increased intake of CoQ10 has been associated to benefit heart health and immunity. CoQ10 is commonly used in cosmetic products for its anti-aging properties.

For further details please log on to: http://nutra.dsm.com

DSM develops compressible CoQ10 for supplements


3/21/2005- DSM Nutritional Products has developed a new compressible form of Coenzyme Q10, which it says will enable supplement manufacturers to incorporate the naturally occurring compound in tablet formulations.

Called all-Q CoQ10 10 per cent TG/P, the beadlets - produced from chicken gelatine using a patented process - were unveiled to the market last week at Expo West/Supply Expo in Anaheim.

CoQ10 is believed to help cells convert oxygen into energy and function efficiently. Recent studies indicating that it could aid cardiovascular health and help slow the progression of Parkinson's disease have triggered a huge surge in demand.

Lynda Doyle, DSM's director of business development, said all-Q "enables supplement developers to address the growing demand for CoQ10" by expanding the delivery options. It facilitates the coenzyme's use in supplements such as multivitamin and single-entity tablets, antioxidant tablets and two-piece hard shell gelatin tablets.

Doyle explained to NutraIngredients-USA.com that, until now, compressing COQ10 into tablet form had proved problematic. She said that competing brands experienced 100 percent extrusion loss, compared with just 1.9 percent for all-Q.

As well as this superior stability, all-Q's bioavailability is said to be equivalent to that of market leading CoQ10 for use in beverages - an important factor for formulators since high bioavailability means they do not need to use so much.

At the beginning of this year the price of CoQ10 was reported to have reached a record high of between $3,000 and $4,000 per kg. The effects of the high demand and a trend amongst consumers to take higher doses were compounded by the coenzyme's recent reclassification from a drug to a food in Japan, where most of the world's supply originates.

In January Soft Gel Technologies announced that it had developed a completely solubilized form of CoQ10 and carried out a small trial that suggested it to be more 2.5 percent more bioavailable than traditional CoQ10 softgels.

The heat produced during commercial production of CoQ10 results in the formation of crystals, which have a reduced surface area and solubility. Soft Gel said its patent-pending technology, which requires no synthetic surfactants, involves dissolving the crystals and preventing them from reforming. This means that the product is completely soluble at room temperature and therefore more readily absorbed by the body.

Do you take Q10, and if so what level? Does it do anything for you?
Thanks,
Dan

I take 600 mg of Q10 (Puritans Pride) daily. I've been taking Q10 for the past 18? months. My neuro told me to take 1200 mg. Does it help? I don't know. I do take a lot of stuff and I have no idea which drug or supplement works to slow or stop progression (except for Sinemet and Mirapex which provide symtom relief). I do seem to have held my own over the past 40 months however with not much change in total dosage of Sinemet/Mirapex.
Ashley

ashleyk,
Please see Carolyn's thread on Can Sound Slow Parkinson progression. Towards the end is a statment that says "Findings from a small study (with only 80 participants) at the University of California, San Diego, suggest that taking 1,200 mg per day of coenzyme Q (CoQ10) can also help slow progression of the disease in its early stages, although these are very high doses and quality supplements can be quite expensive. Before we can say for sure that CoQ10 helps, the results must be confirmed in larger studies."

Hope this helps

GregD

My Dr recently recommended I take 1200mg per day and said to shuold use Vitaline becasue that was the studied CoQ10. He warned me the cost was high, but when I called, they told me I could get 30% off my opening order. I feel better about trying it at the lower cost.

Jaal, that study was in 2002, I think, and since then there have been newer and better formulations.

I am sure there have been more between then and now, but have they been studies? I asked my Dr about just taking some from the local drug store, but he is a firm believer in Vitaline due to the studies. So far so good for me.